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Anti-SARS-CoV-2 NTD antibody (1C2)

Catalog #:   RVV00206 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, WB
Expression system: Mammalian Cells
Overview

Catalog No.

RVV00206

Expression system

Mammalian Cells

Species reactivity

SARS-CoV-2 (2019-nCoV)

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

N-terminal domain,NTD,Spike glycoprotein,S glycoprotein,E2,Peplomer protein,Spike protein S1,S

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P0DTC2

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

1C2

Data Image
References

Structural Analysis of the SARS-CoV-2 Spike N-Terminal Domain Across Wild-Type and Recent Variants: A Comparative Study., PMID:40485545

Is SARS-CoV-2 Spike Evolution Being Retargeted at the N-Terminal Domain?, PMID:40415355

Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein., PMID:40308784

Characterization of Nanobody Binding to Distinct Regions of the SARS-CoV-2 Spike Protein by Flow Virometry., PMID:40285013

Spike Protein-Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?, PMID:40242590

Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses., PMID:40226608

Allosteric Control and Glycan Shielding Adaptations in the SARS-CoV-2 Spike from Early to Peak Virulence., PMID:40161746

Conformational and Stability Analysis of SARS-CoV-2 Spike Protein Variants by Molecular Simulation., PMID:40137759

Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants., PMID:40136024

Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability., PMID:40135879

Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern., PMID:40043139

NIEAs elicited by wild-type SARS-CoV-2 primary infection fail to enhance the infectivity of Omicron variants., PMID:39994733

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals., PMID:39896663

Decoding omicron: Genetic insight into its transmission dynamics, severity spectrum and ever-evolving strategies of immune escape in comparison with other SARS-CoV-2 variants., PMID:39889436

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections., PMID:39807166

Development of a two-component recombinant vaccine for COVID-19., PMID:39759508

Enhanced antibody response to the conformational non-RBD region via DNA prime-protein boost elicits broad cross-neutralization against SARS-CoV-2 variants., PMID:39727342

Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines., PMID:39713412

Cross-neutralization of distant coronaviruses correlates with Spike S2-specific antibodies from immunocompetent and immunocompromised vaccinated SARS-CoV-2-infected patients., PMID:39678346

Prompt engineering-enabled LLM or MLLM and instigative bioinformatics pave the way to identify and characterize the significant SARS-CoV-2 antibody escape mutations., PMID:39657873

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV., PMID:39644492

Defining the features and structure of neutralizing antibody targeting the silent face of the SARS-CoV-2 spike N-terminal domain., PMID:39619228

Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain., PMID:39605558

Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV., PMID:39589795

Exploring B-cell epitope conservation and antigenicity shift in current COVID-19 variants: Analyzing spike-antibody interactions for therapeutic uses., PMID:39531907

Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harbouring both NTD and RBD potent antibodies., PMID:39470577

Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection., PMID:39405332

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain., PMID:39361729

Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families., PMID:39292703

Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants., PMID:39282390

N121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization., PMID:39221474

Glycan masking of NTD loops with a chimeric RBD of the spike protein as a vaccine design strategy against emerging SARS-CoV-2 Omicron variants., PMID:39192804

Concerted deletions eliminate a neutralizing supersite in SARS-CoV-2 BA.2.87.1 spike., PMID:39173622

Recombination Events Among SARS-CoV-2 Omicron Subvariants: Impact on Spike Interaction With ACE2 Receptor and Neutralizing Antibodies., PMID:39149136

Enhanced Assessment of Cross-Reactive Antigenic Determinants within the Spike Protein., PMID:39125749

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination., PMID:39094579

Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence., PMID:39018495

Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid., PMID:39018397

Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency., PMID:38975334

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2., PMID:38933606

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions., PMID:38900807

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes., PMID:38848216

Antigenic Characterization of Circulating and Emerging SARS-CoV-2 Variants in the U.S. throughout the Delta to Omicron Waves., PMID:38793756

SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1., PMID:38779718

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern., PMID:38766244

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain., PMID:38740785

Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1., PMID:38616729

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV., PMID:38558973

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination., PMID:38545622

Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features., PMID:38467646

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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Anti-SARS-CoV-2 NTD antibody (1C2) [RVV00206]
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