Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies. PMID: 26778617
Characterization of a novel polyclonal anti-hypusine antibody. PMID: 24024105
Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens. PMID: 9748364
Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine and tyrosine and O-glycosylated in Trichomonas vaginalis. PMID: 22212642
Polyamines and their derivatives as modulators in growth and differentiation. PMID: 2697982
Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco. PMID: 1542563
Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis. PMID: 26410361
Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging. PMID: 12210765
Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine in Saccharomyces cerevisiae. PMID: 8325852
Identification of two novel Trichomonas vaginalis eif-5a genes. PMID: 20060503
eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes. PMID: 30733517
Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva. PMID: 15262146
Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase. PMID: 15039063
cDNA and derived amino acid sequence of the hypusine containing protein from Dictyostelium discoideum. PMID: 2540042
Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax. PMID: 17042947
Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation. PMID: 24220243
Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity. PMID: 16941339
Deoxyhypusine synthase from rat testis: purification and characterization. PMID: 7721768
The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein. PMID: 17707773
Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA. PMID: 10790432
Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. PMID: 10381392
Mass spectrometrical analysis of bilin-binding protein from the wing of Hebomoia glaucippe (Linnaeus, 1758) (Lepidoptera: Pieridae). PMID: 22740467
Detection of the hypusine-containing protein (HP = eIF-5A) in crude yeast extracts by two-dimensional western blots. PMID: 1281091
Helicobacter pylori in gastric cancer and peptic ulcer disease in a Colombian population. Strain heterogeneity and antibody profiles. PMID: 11683922
A dual-function [Ru(bpy)3]2+ encapsulated metal organic framework for ratiometric Al3+ detection and anticounterfeiting application. PMID: 36866710
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. PMID: 30257869
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment. PMID: 34273022
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis. PMID: 35448531
The hypusine-containing translation factor eIF5A. PMID: 25029904
Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation. PMID: 8347280
Dietary spermidine improves cognitive function. PMID: 33852843
Hypusine: a new target for therapeutic intervention in diabetic inflammation. PMID: 20670594
Is hypusine essential for eukaryotic cell proliferation? PMID: 8108861
Polyamine metabolism is a central determinant of helper T cell lineage fidelity. PMID: 34216540
Functional significance of eIF5A and its hypusine modification in eukaryotes. PMID: 19997760
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer. PMID: 27357307
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. PMID: 34105442
Hypusine is essential for eukaryotic cell proliferation. PMID: 9285094
Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line. PMID: 23701550
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. PMID: 17476569
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. PMID: 31130465
Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions. PMID: 30208826
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype. PMID: 34496231
YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. PMID: 35177822
Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy. PMID: 35216170
Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria. PMID: 17100634
Polyamines reverse immune senescence via the translational control of autophagy. PMID: 31679458
The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A). PMID: 16452303
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. PMID: 31474573
Hypusine biosynthesis in protein and its biological consequences. PMID: 3151230
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A. PMID: 9285092
Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer. PMID: 35100927
Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. PMID: 32235505
At the hypusine of the crime. PMID: 22763665
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. PMID: 31796630
The effect of hypusine modification on the intracellular localization of eIF5A. PMID: 19379712
Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A. PMID: 36735910
A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. PMID: 25261239
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. PMID: 33852845
Biosynthesis of hypusine in eIF-4D precursors. PMID: 3151229
Protein-protein-interaction network organization of the hypusine modification system. PMID: 22888148
Biological Relevance and Therapeutic Potential of the Hypusine Modification System. PMID: 26037925
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. PMID: 36057633
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder. PMID: 35858628
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. PMID: 33303756
Hypusine-containing protein eIF5A promotes translation elongation. PMID: 19424157
Polyamines. PMID: 6206782
Growth of studies on hypusine in biological systems. PMID: 9285093
Development of orthogonally protected hypusine for solid-phase peptide synthesis. PMID: 25769022
The polyamine-hypusine circuit controls an oncogenic translational program essential for malignant conversion in MYC-driven lymphoma. PMID: 37070973
Hypusine, N6-(4-amino-2-hydroxybutyl)-2,6-diaminohexanoic acid, in tissue proteins of mammals. PMID: 4748368
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. PMID: 35007708
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. PMID: 33811703
Modulation by hypusination. PMID: 31534233
Completing the hypusine pathway in Plasmodium. PMID: 19740108
The function of the hypusine-containing proteins of yeast and other eukaryotes is well conserved. PMID: 7969034
Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered. PMID: 3119589
Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D. PMID: 6403941
Specific and sensitive GC-MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study. PMID: 35243537
Hypusine, a new amino acid occurring in bovine brain. Isolation and structural determination. PMID: 4334286
Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome. PMID: 27196944
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. PMID: 27041563
Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA. PMID: 11060315
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. PMID: 36058905
Isolation and identification of alpha-(gamma-aminobutyryl)-hypusine. PMID: 3950619
Flexible NAD+ Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A. PMID: 32752130
The mammalian hypusine-containing protein, eukaryotic initiation factor 4D. Structural homology of this protein from several species. PMID: 6423643
Distribution of alpha-(gamma-aminobutyryl)-hypusine. PMID: 3100722
Functions of Polyamines in Mammals. PMID: 27268251
Down-regulation of hypusine biosynthesis in Plasmodium by inhibition of S-adenosyl-methionine-decarboxylase. PMID: 19949824
Hypusine formation in protein by a two-step process in cell lysates. PMID: 3117792
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases. PMID: 21360085
Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma. PMID: 29295892
Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. PMID: 27306458
Polyamines in Eukaryotes, Bacteria, and Archaea. PMID: 27268252
The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine). PMID: 6806267
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine. PMID: 18451031
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides. PMID: 3114263
Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. PMID: 30661771
A rapid and sensitive method for the determination of hypusine in proteins and its distribution and developmental changes. PMID: 6430351
Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor. PMID: 6789324
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). PMID: 20942800
Eukaryotic initiation factor 5A hypusine as a negative regulator of adenosine 2B receptor (A2bAR) through interaction with stem loop sequences within the A2bAR 3'-untranslated region. PMID: 36689050
Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts. PMID: 9066781
Cloning and characterization of hypusine-containing protein eIF5A from the olive flounder Paralichthys olivaceus. PMID: 19344779
Excretion of hypusine by children and by patients with familial hyperlysinemia. PMID: 4753051
Cryptosporidium parvum has an active hypusine biosynthesis pathway. PMID: 24893338
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes. PMID: 3119588
The function of spermine. PMID: 24395705
Modulation of protein synthesis by polyamines. PMID: 25906835
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells. PMID: 9149130
Changes in eIF-4D hypusine modification or abundance are not correlated with translational repression in HeLa cells. PMID: 3091607
Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth. PMID: 6817926
Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells. PMID: 9804167
The archaebacterial hypusine-containing protein. Structural features suggest common ancestry with eukaryotic translation initiation factor 5A. PMID: 1541288
Distribution of hypusine, N 6 -(4-amino-2-hydroxybutyl)-2,6-diaminohexanoic acid, in mammalian organs. PMID: 5141831
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs. PMID: 8947467
Development of a Hypusine Reagent for Peptide Synthesis. PMID: 11671715
The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation. PMID: 24178473
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. PMID: 20501948
Zhang, T., Fu, W., Zhang, H., Li, J., Xing, B., Cai, Y., Zhang, M., Liu, X., Qi, C., Qian, L., et al. (2024). Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression. Nature Cell Biology.
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