Catalog No.
YHJ72801
Description
IL36RN (Interleukin 36 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL36RN include Psoriasis 14, Pustular and Pustulosis Palmaris Et Plantaris.Among its related pathways are IL-1 Family Signaling Pathways and PEDF Induced Signaling.Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. IL36RN may be the major disease-causing gene in generalized pustular psoriasis patients in Han population in Sichuan region of China. IL36RN mutations were strongly linked with early onset and hyponychial pustules, but not with therapeutic efficacy of acitretin or recurrence frequency.
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys12-Phe151
Predicted molecular weight
17.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBH0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FIL1D, Interleukin-1 family member 5, IL-36Ra, IL1HY1, Interleukin-36 receptor antagonist protein, IL1RP3, IL-1RP3, IL-1ra homolog 1, Interleukin-1-like protein 1, IL-1-related protein 3, IL1L1, Interleukin-1 HY1, IL-1HY1, Interleukin-1 delta, FIL1 delta, IL-1 delta, IL-1L1, Interleukin-1 receptor antagonist homolog 1, IL36RN, IL1F5, IL-1F5
Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson's disease., PMID:40368903
Enhanced IL36RN Expression and Its Association With Immune Microenvironment Predicts Poor Prognosis in Gastric Cancer., PMID:40347070
Epidemiological, Genetic, Clinical, and Treatment Differences of Generalized Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Across Ethnicities: A Systematic Review., PMID:40169503
Spesolimab for the Treatment of Generalized Pustular Psoriasis Flares., PMID:40043276
Analysis of the German Compassionate Use Program on spesolimab in patients with generalized pustular psoriasis: evidence outside of clinical trials., PMID:39912471
Case report: Successful treatment with spesolimab of acrodermatitis continua of Hallopeau in an older patient without IL36RN mutations., PMID:39882245
Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease., PMID:39800261
Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease., PMID:39698752
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
IL36RN Mutations and Correlated Characteristics in Generalized Pustular Psoriasis Patients in Can Tho City, Vietnam: A Cross-Sectional Study., PMID:39378855
Spesolimab, the first-in-class anti-IL-36R antibody: From bench to clinic., PMID:39373152
A case of revertant mosaic-like normal-looking spots in a patient with erythroderma with IL36RN and CARD14 heterozygous mutations., PMID:39373130
Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab., PMID:39301845
TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis., PMID:39279150
Autoantibody mediated deficiency of IL-36-receptor antagonist in a subset of patients with psoriasis and psoriatic arthritis., PMID:39265919
Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval., PMID:39104539
Erythema multiforme after initiating spesolimab in a patient with generalized pustular psoriasis with IL36RN mutation., PMID:39015980
TNFRSF11A variants contribute to systemic autoinflammatory diseases: A case series of 12 patients., PMID:39003954
Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory., PMID:38892277
Characteristics of psoriatic plaques in generalized pustular psoriasis patients with or without IL36RN mutation., PMID:38822916
Use of biologics in Chinese pregnant patients with deficiency of interleukin-36 receptor antagonist (DITRA): A case series., PMID:38802208
CXCL5/CXCL8 induces neutrophilic inflammation in peri-implantitis., PMID:38699841
Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population., PMID:38651209
Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report., PMID:38571950
Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab., PMID:38565205
Acquired diffuse palmoplantar erythema with keratoderma in Chinese patients with pustular psoriasis: A predictor for IL36 receptor antagonist c.115+6T>C mutation?, PMID:38488485
Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis., PMID:38414093
Paediatric pustulotic arthro-osteitis patient with an IL36RN variant, heterozygous c.115+6T>C, who was successfully treated with tonsillectomy: A case report and literature review., PMID:38284206
Spesolimab, A Novel Interleukin-36 Inhibitor for Generalized Pustular Psoriasis Flares in Adult Patients., PMID:38271532
Clinical advances in biological therapy for generalized pustular psoriasis: a review., PMID:38247394
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases., PMID:38189700
Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications., PMID:38103162
The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab., PMID:38077370
Acute generalized exanthematous pustulosis caused by hydroxychloroquine in a patient with rheumatoid arthritis and CARD14 mutation: Case report., PMID:38013380
Mature IL-36γ Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin., PMID:37827276
Cutaneous findings and treatments in deficiency of interleukin-36 receptor antagonist (DITRA): A review of the literature., PMID:37726967
Expression of interleukin-36 receptor antagonist in a patient with generalized pustular psoriasis harboring the p.Pro82Leu variant in the IL36RN gene., PMID:37525499
In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex., PMID:37414245
Genetics of Generalized Pustular Psoriasis: Current Understanding and Implications for Future Therapeutics., PMID:37372477
Transcriptomic responses of peripheral blood mononuclear cells to cyclosporin and etanercept in a female infant with juvenile generalized pustular psoriasis., PMID:37194367
Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?, PMID:37057764
Deficiency of interleukin-36 receptor antagonist (DITRA): An analysis of 58 Chinese patients in a tertiary hospital in Taiwan., PMID:36843341
Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia., PMID:36843152
Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population., PMID:36804966
Current management of generalized pustular psoriasis., PMID:36779681
Case report: Infantile generalized pustular psoriasis with IL36RN and CARD14 gene mutations., PMID:36704338
A viewpoint on the genetic determinants of generalised pustular psoriasis., PMID:36645252
A homozygous loss-of-function variant in the MPO gene is associated with generalized pustular psoriasis., PMID:36585391
Different Clinical Features of Pediatric Generalized Pustular Psoriasis in Patients with or without IL36RN Variants., PMID:36577391
Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis., PMID:36331855
For research use only. Not for human or drug use.
