Catalog No.
YHF79501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser497
Predicted molecular weight
58.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P98170
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ILP, IAP-like protein, X-linked inhibitor of apoptosis protein, IAP-3, hILP, X-linked IAP, Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, RING-type E3 ubiquitin transferase XIAP, E3 ubiquitin-protein ligase XIAP, API3, XIAP, hIAP-3, hIAP3, BIRC4, IAP3
A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma., PMID:40486906
Jun N-Terminal Kinase Inhibitor Suppresses CASK Deficiency-Induced Cerebellar Granular Cell Death in MICPCH Syndrome Model Mice., PMID:40422253
Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome., PMID:40419769
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells., PMID:40409732
Limocitrin induced cellular death through ERK pathways in human oral squamous cell cancer., PMID:40404781
ABT-263, a BCL-2 inhibitor, selectively eliminates latently HIV-1-infected cells without viral reactivation., PMID:40392781
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases., PMID:40378821
Epstein-Barr virus infection plays a crucial role in triggering hemophagocytic lymphohistiocytosis in patients with X-linked inhibitor of apoptosis protein deficiency., PMID:40360445
[Effect of Biyan Jiedu Capsules on proliferation and apoptosis of nasopharyngeal carcinoma cells based on PI3K/Akt pathway]., PMID:40350884
Monitoring dimer structure orientation of full-length XIAP in living cells using a bioluminescence-based complementation assay., PMID:40334897
Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis., PMID:40308566
Late presentation of X-linked inhibitor of apoptosis (XIAP) deficiency in a young adult., PMID:40301935
In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells., PMID:40296721
Genetic analysis of a female patient with X-linked lymphoproliferative disease type 2: a case report., PMID:40296086
Naphthalimide derivative attenuates tumor growth of wild-type p53-expressing U87 glioma cells in vitro and in vivo through a biphasic dose-dependent mechanism: A switch from cell cycle to apoptosis., PMID:40294493
Cnidaria XIAP activates caspase-mediated cell death., PMID:40288723
Identification of novel long non-coding RNA involved in Sertoli cell of non-obstructive azoospermia based on microarray and bioinformatics analysis., PMID:40280502
Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming., PMID:40272637
Mechanistic and metabolic exploration of neohesperidin against lung cancer cell lines through ROS-mediated mitochondrial apoptosis: An in-silico and in-vitro approach., PMID:40252982
Intelectin-1 promotes granulosa cells proliferation and modulates apoptosis via ERK1/2, AKT, and insulin receptor signaling pathways in Large White and Meishan pigs., PMID:40250633
Expression Pattern Study of miR-200a and XIAP Gene in the Non-small Cell Lung Cancer Patients’ Blood., PMID:40223411
The effect of Entamoeba histolytica lectin antigen and microRNA-643 on the development of microsatellite instability (MSI) in colorectal adenocarcinoma., PMID:40211226
HBx induces chemoresistance in diffuse large B cell lymphoma by inhibiting intrinsic apoptosis via the NF-κB/XIAP pathway., PMID:40207019
The class A scavenger receptor member 3 (SCARA3) regulates cell apoptosis through X-linked apoptosis inhibitory protein (XIAP) in turbot (Scophthalmus maximus L.)., PMID:40194751
Inhibition of Interleukin-8/C-X-C Chemokine Receptor 2 Signaling Axis Prevents Tumor Growth and Metastasis in Triple-Negative Breast Cancer Cells., PMID:40188812
The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development., PMID:40146486
XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1., PMID:40133252
Comprehensive flow cytometry-based diagnosis of XIAP deficiency., PMID:40128104
Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling., PMID:40089478
Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism., PMID:40076649
Novel Camptothecin Derivative 9c with Enhanced Antitumor Activity via NSA2-EGFR-P53 Signaling Pathway., PMID:40076615
SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation., PMID:40069146
Elevated COMMD1 Contributes to Cardiomyocyte Copper Efflux in Chronic Myocardial Ischemia: Insights From Rhesus Monkey., PMID:40032621
Imipramine-induced Apoptosis and Metastasis Inhibition in Human Bladder Cancer T24 Cells Through EGFR/ERK/NF-κB Pathway Suppression., PMID:40010952
Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS-mutant Nonsmall Cell Lung Cancer., PMID:39992860
Importin α/β inhibition as a strategy to modulate cancer drug resistance and XIAP nuclear translocation., PMID:39919389
The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma., PMID:39917292
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis., PMID:39905808
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with 'persister' cell profiles fail to benefit from adjuvant chemotherapy., PMID:39886119
Etoposide-loaded lipopolymer nanoparticles promote Smac minetic activity against inhibitor of apoptosis protein for glioblastoma treatment., PMID:39879864
An Azomethine Derivative, BCS3, Targets XIAP and cIAP1/2 to Arrest Breast Cancer Progression Through MDM2-p53 and Bcl-2-Caspase Signaling Modulation., PMID:39770487
IL-18 and IL-18BP: A Unique Dyad in Health and Disease., PMID:39769266
An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR., PMID:39695179
Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment., PMID:39667542
Mechanisms of H2pmen-Induced cell death: Necroptosis and apoptosis in MDA cells, necrosis in MCF7 cells., PMID:39660197
E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury., PMID:39629879
RNA-binding protein HuR inhibition induces multiple programmed cell death in breast and prostate cancer., PMID:39627778
XAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signaling., PMID:39615106
Identification of a New Role of miR-199a-5p as Factor Implied in Neuronal Damage: Decreasing the Expression of Its Target X-Linked Anti-Apoptotic Protein (XIAP) After SCI., PMID:39596440
Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies., PMID:39596160