Catalog No.
YHE19401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu34-Glu125
Predicted molecular weight
12.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36897
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activin receptor-like kinase 5, ALK-5, TGFBR1, TGFR-1, ALK5, Transforming growth factor-beta receptor type I, TGF-beta type I receptor, TbetaR-I, SKR4, Activin A receptor type II-like protein kinase of 53kD, TGF-beta receptor type I, TGF-beta receptor type-1, Serine/threonine-protein kinase receptor R4
Co-blockade of TGFβ and PD-1 reinvigorates glioblastoma-infiltrating CD8+ T cells that characteristically upregulate TGFβR expression., PMID:40459502
Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system., PMID:40445987
Finerenone alleviates the high glucose-induced fibrosis in HK-2 cells by inhibiting EMT via the TGF-β1/Smads signaling., PMID:40436765
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1., PMID:40394630
Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling., PMID:40382656
MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis., PMID:40335825
Prenatal Detection of TGFBR1 Variant Associated With Severe Ventriculomegaly and Loeys-Dietz Syndrome., PMID:40325597
Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination., PMID:40315672
Cytokines from parasites: manipulating host responses by molecular mimicry., PMID:40302223
Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells., PMID:40277917
In Silico-Designed TGFβRI/TGFβRII Receptor Complex Peptide Inhibitors Exhibit Biological Activity In Vitro., PMID:40245195
Analysis of FBN1, TGFβ2, TGFβR1 and TGFβR2 mRNA as Key Molecular Mechanisms in the Damage of Aortic Aneurysm and Dissection in Marfan Syndrome., PMID:40243722
Imidazole-Based ALK5 Inhibitor Attenuates TGF-β/Smad-Mediated Hepatic Stellate Cell Activation and Hepatic Fibrogenesis., PMID:40211771
M2 macrophage-derived exosomes reverse TGF-β1-induced epithelial mesenchymal transformation in BEAS-2B cells via the TGF-βRI/Smad2/3 signaling pathway., PMID:40211426
A quiescence-like/TGF-β1-specific CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML., PMID:40184725
miR-16-5p Regulates Proliferation and Apoptosis in High Glucose-Treated Human Retinal Microvascular Endothelial Cells by Targeting VEGFA and TGFBR1., PMID:40166052
Discovery of novel transforming growth factor β type 1 receptor inhibitors through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation in hepatocellular carcinoma., PMID:40163974
Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cells., PMID:40148545
Nephrectomy Induces Severe Bone Loss in Mice Expressing Constitutively Active TGFβ Receptor Type I., PMID:40141345
Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity., PMID:40133308
Interactions of flavonoid and coumarin derivative compounds with transforming growth factor-beta receptor 1 (TGF-βR1): integrating virtual screening, molecular dynamics, maximum common substructure, and ADMET approaches in the treatment of idiopathic pulmonary fibrosis., PMID:40126695
Thiazole isomers as potential ALK5 inhibitors alleviate P2X7R-mediated inflammation during liver fibrosis., PMID:40117804
Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation., PMID:40109260
Discovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy., PMID:40108955
Sirt6 loss activates Got1 and facilitates cleft palate through abnormal activating glycolysis., PMID:40050262
Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling., PMID:40011426
TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts., PMID:39984487
Senescent endothelial cell-derived Galectin 3 promotes silicosis through endothelial-fibroblast and endothelial-macrophage crosstalk., PMID:39955992
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice., PMID:39939465
Identification of TGFBR1 Gene Variants in Two Chinese Pedigrees with Loeys-Dietz Syndrome., PMID:39937695
Multiple Self-Healing Squamous Epithelioma and Loeys-Dietz syndrome: a single TGFBR1 variant, two phenotypes in one patient., PMID:39933850
Identification of Natural Killer Cell Enhancers Through Mimicking of the Tumor Microenvironment., PMID:39932696
Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy., PMID:39904762
Generation of two induced pluripotent stem cell lines from Loeys-Dietz syndrome patients carrying heterologous mutation of TGFBR1., PMID:39884159
Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition., PMID:39874182
Impact and mechanism of the TBX-22 gene mutation G874A on the epithelial-mesenchymal transition in medial edge epithelial cells., PMID:39871035
Interferon regulatory factor 5 attenuates kidney fibrosis through transcriptional suppression of Tgfbr1., PMID:39827667
Bioinformatics Analysis Reveals Microrchidia Family Genes as the Prognostic and Therapeutic Markers for Colorectal Cancer., PMID:39812044
Synthesis and biological evaluation of 4-((3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)quinoline derivatives as novel potential transforming growth factor-β type 1 receptor inhibitors for hepatocellular carcinoma., PMID:39809119
MALAT1 promotes epithelial-mesenchymal transition of pancreatic cancer cells through the miR-141-5p-TGF-ß-TGFBR1/TGFBR2 axis., PMID:39784150
NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression., PMID:39762312
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment., PMID:39759895
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1., PMID:39757225
Salvianic acid A ameliorates atherosclerosis through metabolic-dependent anti-EndMT pathway and repression of TGF-β/ALK5 signaling., PMID:39740380
Gene expression modulation in human aortic smooth muscle cells under induced physiological mechanical stretch., PMID:39732782
Transforming growth factor beta receptor type I (TGF-βRI) kinase inhibitors IOA-359 and IOA-360 stimulate erythropoiesis in MDS., PMID:39727008
Guided monocyte fate to FRβ/CD163+ S1 macrophage antagonises atopic dermatitis via fibroblastic matrices in mouse hypodermis., PMID:39720957
Analysing the relevance of TGF-β and its regulators in cervical cancer to identify therapeutic and diagnostic markers., PMID:39701195
Quantification of Vactosertib an Inhibitor of TGFBR1 by LC-MS/MS in Rat Plasma and Its Pharmacokinetic Profiling., PMID:39697107
For research use only. Not for human or drug use.
