Catalog No.
YHB11501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr141-Lys310
Predicted molecular weight
22.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75164
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysine-specific demethylase 4A, JMJD2, Jumonji domain-containing protein 2A, KDM4A, KIAA0677, JHDM3A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, JMJD2A, JmjC domain-containing histone demethylation protein 3A
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity., PMID:40498073
Carbon black induced pulmonary fibrosis through piR-713551/PIWIL4 targeting THBS2 signal pathway., PMID:40246476
Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis., PMID:40169574
Isoorientin Ameliorates Macrophage Pyroptosis and Atherogenesis by Reducing KDM4A Levels and Promoting SKP1-Cullin1-F-box E3 Ligase-mediated NLRP3 Ubiquitination., PMID:40133580
Mechanism of KDM4A in Regulating Microglial Polarization in Ischemic Stroke., PMID:40080374
Discovery of a first-in-class PROTAC degrader of histone lysine demethylase KDM4., PMID:39978110
Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers., PMID:39975048
GDH1-dependent α-ketoglutarate promotes HBV transcription by modulating histone methylations on the cccDNA minichromosome., PMID:39905842
Glutamine, Serine and Glycine at Increasing Concentrations Regulate Cisplatin Sensitivity in Gastric Cancer by Posttranslational Modifications of KDM4A., PMID:39835657
Analogue-Sensitive Inhibition of Histone Demethylases Uncovers Member-Specific Function in Ribosomal Protein Synthesis., PMID:39808475
KDM4A Silencing Reverses Cisplatin Resistance in Ovarian Cancer Cells by Reducing Mitophagy via SNCA Transcriptional Inactivation., PMID:39791159
HPV11 targeting KDM4A regulates the polarization of macrophage M1 and promotes the development of nasal inverted papilloma., PMID:39696338
KDM4A facilitates neuropathic pain and microglial M1 polarization by regulating BDNF in a rat model of brachial plexus avulsion., PMID:39532465
Targeting N-Methyl-lysine Histone Demethylase KDM4 in Cancer: Natural Products Inhibitors as a Driving Force for Epigenetic Drug Discovery., PMID:39498961
Origins of Catalysis in Non-Heme Fe(II)/2-Oxoglutarate-Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides., PMID:39487094
Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients., PMID:39475132
Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer., PMID:39461328
KDM4A promotes malignant progression of breast cancer by down-regulating BMP9 inducing consequent enhancement of glutamine metabolism., PMID:39300582
Histone H3K9 Methylation Features under Hypoxic Conditions after the HIF1A Knockdown in Mesenchymal Stromal Cells In Vitro., PMID:39259464
Construction of a prognostic model for disulfidptosis-related long noncoding RNAs in R0 resected hepatocellular carcinoma and analysis of their impact on malignant behavior., PMID:39210306
Jumonji histone demethylases are therapeutic targets in small cell lung cancer., PMID:39154123
Spinal nerve transection-induced upregulation of KDM4A in the dorsal root ganglia contributes to the development and maintenance of neuropathic pain via promoting CCL2 expression in rats., PMID:39136140
FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism., PMID:39085849
Kdm4a is an activity downregulated barrier to generate engrams for memory separation., PMID:39003305
[Advances in Targeted Therapy for Malignant Pleural Mesothelioma]., PMID:38880927
The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma., PMID:38878485
JMJD2A promotes the development of castration-resistant prostate cancer by activating androgen receptor enhancer and inhibiting the cGAS-STING pathway., PMID:38818897
Histone demethylase KDM4A mediating macrophage polarization: A potential mechanism of trichloroethylene induced liver injury., PMID:38800986
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A., PMID:38781256
Functional mechanism of hypoxia-like conditions mediating resistance to ferroptosis in cervical cancer cells by regulating KDM4A SUMOylation and the SLC7A11/GPX4 pathway., PMID:38727079
Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration., PMID:38691277
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma., PMID:38508144
KDM4A-AS1 Promotes Cell Proliferation, Migration, and Invasion via the miR-4306/STX6 Axis in Hepatocellular Carcinoma., PMID:38505873
Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability., PMID:38464252
The MYC-NFATC2 axis maintains the cell cycle and mitochondrial function in acute myeloid leukaemia cells., PMID:38459421
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity., PMID:38390756
Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer., PMID:38309723
In-silico guided chemical exploration of KDM4A fragments hits., PMID:38129913
Retraction: Cui S-Z, Lei Z-Y, Guan T-P, et al. Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy. Cancer Science. 2020; 111: 1567-1581. https://doi.org/10.1111/cas.14375., PMID:38078665
Astrocyte KDM4A mediates chemokines and drives neutrophil infiltration to aggravate cerebral ischemia and reperfusion injury., PMID:38008899
Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis., PMID:37988559
The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis., PMID:37873881
SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A., PMID:37870957
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation., PMID:37845773
Activity Guided Azide-methyllysine Photo-trapping for Substrate Profiling of Lysine Demethylases., PMID:37703462
Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1., PMID:37553362
The Novel Role of Zfp296 in Mammalian Embryonic Genome Activation as an H3K9me3 Modulator., PMID:37511136
MiR-137 promotes TLR4/NF-κB pathway activity through targeting KDM4A, inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells and aggravates osteoporosis., PMID:37344864
JMJD2A participates in cytoskeletal remodeling to regulate castration-resistant prostate cancer docetaxel resistance., PMID:37165308
Machine learning-based construction of a ferroptosis and necroptosis associated lncRNA signature for predicting prognosis and immunotherapy response in hepatocellular cancer., PMID:37152064
For research use only. Not for human or drug use.
