Catalog No.
YVV01001
Expression system
E. coli
Species
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Protein length
Met1-Gly180
Predicted molecular weight
21.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>85% as determined by SDS-PAGE.
Accession
P0DTD1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Host translation inhibitor nsp1, Leader protein, Non-structural protein 1, nsp1, Replicase polyprotein 1ab, pp1ab, ORF1ab polyprotein
SARS-CoV-2 Nsp1-Resistant Modified RNA for the Creation of Nsp1-Responsive Systems., PMID:40470631
A Novel Toolkit of SARS-CoV-2 Sub-Genomic Replicons for Efficient Antiviral Screening., PMID:40431609
Nsp1 stalls DNA polymerase α at DNA hairpins., PMID:40399356
SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals., PMID:40359110
Impact of SARS-CoV-2 Wuhan and Omicron Variant Proteins on Type I Interferon Response., PMID:40285011
Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2., PMID:40244295
Differential clearance rate of proteins encoded on a self-amplifying mRNA COVID-19 vaccine in muscle and lymph nodes., PMID:40236291
The differential effect of SARS-CoV-2 NSP1 on mRNA translation and stability reveals new insights linking ribosome recruitment, codon usage, and virus evolution., PMID:40193709
The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition., PMID:40153437
Distinct Roles of SARS-CoV-2 N Protein and NFP in Host Cell Response Modulation., PMID:40107650
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms., PMID:39932490
SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals., PMID:39868184
Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations., PMID:39724814
Naturally occurring N-terminal mutations in SARS-CoV-2 nsp1 impact innate immune modulation but do not affect virus virulence., PMID:39651192
Structure-function mapping and mechanistic insights on the SARS CoV2 Nsp1., PMID:39584680
Mutational and evolutionary dynamics of non-structural and spike proteins from variants of concern (VOC) of SARS-CoV-2 in India., PMID:39488303
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients., PMID:39460899
T Cell Peptide Prediction, Immune Response, and Host-Pathogen Relationship in Vaccinated and Recovered from Mild COVID-19 Subjects., PMID:39456150
Honeysuckle-Derived miR2911 Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Targeting Viral Gene Regions., PMID:39339827
Nsp1 stalls DNA Polymerase α at DNA hairpins., PMID:39282423
The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression., PMID:39231808
Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes., PMID:39214998
Requirement of the N-terminal region of nonstructural protein 1 in cis for SARS-CoV-2 defective RNA replication., PMID:39194239
Ribosome stalling during c-myc translation presents actionable cancer cell vulnerability., PMID:39161732
Identification of potential SARS-CoV-2 Nsp1 inhibitors from Piper sarmentosum Roxb. using molecular docking., PMID:39154269
Broad-Spectrum Antiviral Agents against SARS-CoV-2 Variants Inhibit the Conserved Viral Protein Nsp1-RNA Interaction., PMID:39132967
Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis., PMID:39061157
Binding of SARS-CoV-2 Nonstructural Protein 1 to 40S Ribosome Inhibits mRNA Translation., PMID:39007765
A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications., PMID:38997518
Natural-Target-Mimicking Translocation-Based Fluorescent Sensor for Detection of SARS-CoV-2 PLpro Protease Activity and Virus Infection in Living Cells., PMID:38928340
Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis., PMID:38900816
Mutation prediction in the SARS-CoV-2 genome using attention-based neural machine translation., PMID:38872567
SARS-CoV-2 Nsp1 traps RNA in the nucleus to escape immune detection., PMID:38843251
High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms., PMID:38841886
Development of a Cell Culture Model for Inducible SARS-CoV-2 Replication., PMID:38793589
Deletion of 82-85 N-Terminal Residues in SARS-CoV-2 Nsp1 Restricts Virus Replication., PMID:38793572
Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis., PMID:38768348
Copper(II) coordination to the intrinsically disordered region of SARS-CoV-2 Nsp1., PMID:38722808
Characterization of nsp1 Binding to the Viral RNA Leader Sequence of Severe Acute Respiratory Syndrome Coronavirus., PMID:38718213
Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication., PMID:38593595
SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease., PMID:38538957
SARS-CoV-2 targets ribosomal RNA biogenesis., PMID:38427561
Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling., PMID:38411085
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections., PMID:38385526
Antiviral responses versus virus-induced cellular shutoff: a game of thrones between influenza A virus NS1 and SARS-CoV-2 Nsp1., PMID:38375361
SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA., PMID:38335237
Epigenetic repression of antiviral genes by SARS-CoV-2 NSP1., PMID:38277395
Structural Insights into SARS-CoV-2 Nonstructural Protein 1 Interaction with Human Cyclophilin and FKBP1 to Regulate Interferon Production., PMID:38241259
Coronavirus takeover of host cell translation and intracellular antiviral response: a molecular perspective., PMID:38200146
Analysis of SARS-CoV-2 genome evolutionary patterns., PMID:38197644
For research use only. Not for human or drug use.
