Catalog No.
YHJ16001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln251-Asn508
Predicted molecular weight
31.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86UX2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inter-alpha-trypsin inhibitor heavy chain H5, KIAA1953, Inter-alpha-inhibitor heavy chain 5, ITI-HC5, ITI heavy chain H5, ITIH5
Chronic gingivitis increases the risk of early-onset Alzheimer's disease., PMID:40320792
Mendelian Randomization Analysis of the Possible Causal Relationships Between Neurodevelopment-Related Proteins and Bipolar Disorder., PMID:40123161
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction., PMID:39994656
Multitranscriptome analysis reveals stromal cells in the papillary dermis to promote angiogenesis in psoriasis vulgaris., PMID:39569441
High Expression of the Tumor Suppressor Protein ITIH5 in Cholangiocarcinomas Correlates with a Favorable Prognosis., PMID:39518085
Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice., PMID:39198923
Serum ITIH5 as a novel diagnostic biomarker in cholangiocarcinoma., PMID:38475675
ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration., PMID:38375974
An Overview on the Emerging Role of the Plasma Protease Inhibitor Protein ITIH5 as a Metastasis Suppressor., PMID:38355846
ITIH5 inhibits proliferation, adipogenic differentiation, and secretion of inflammatory cytokines of human adipose stem cells-A new key in treating obesity?, PMID:38095340
ITIH5, as a predictor of prognosis and immunotherapy response for P53-like bladder cancer, is related to cell proliferation and invasion., PMID:37431189
White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy., PMID:36139547
Urine inter-alpha-trypsin inhibitor family-related proteins may serve as biomarkers for disease activity of lupus., PMID:35870194
Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma., PMID:35238419
ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro., PMID:35158755
BST-1 as a serum protein biomarker involved in neutrophil infiltration in schizophrenia., PMID:34870552
Enhancer RNA SLIT2 Inhibits Bone Metastasis of Breast Cancer Through Regulating P38 MAPK/c-Fos Signaling Pathway., PMID:34722297
ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids., PMID:34650698
ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4., PMID:33935281
The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells., PMID:33924987
Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement., PMID:33923324
Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5., PMID:33024269
Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin., PMID:32799206
ITIH5 and ECRG4 DNA Methylation Biomarker Test (EI-BLA) for Urine-Based Non-Invasive Detection of Bladder Cancer., PMID:32046186
Genetic effects on planum temporale asymmetry and their limited relevance to neurodevelopmental disorders, intelligence or educational attainment., PMID:31887566
Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease., PMID:29626357
Chronic sun exposure is associated with distinct histone acetylation changes in human skin., PMID:29150847
ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death., PMID:28940371
Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer., PMID:28289921
ITIH5 mediates epigenetic reprogramming of breast cancer cells., PMID:28231808
Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesis., PMID:28059468
[Tumorigenesis from a pathological perspective : Tumor spread and epigenetically regulated genes in bladder cancer]., PMID:27613302
Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-α-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor β1 (TGFβ1)-dependent Fibroblast to Myofibroblast Differentiation., PMID:27143355
Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome., PMID:26252352
All is balanced: inter-α-trypsin inhibitors as unseen extracellular matrix proteins in epidermal morphology and differentiation., PMID:26014118
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood., PMID:25861810
Identification of novel adipokines in the joint. Differential expression in healthy and osteoarthritis tissues., PMID:25853553
Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models., PMID:25809190
Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype., PMID:25093535
Decreased ITIH5 expression is associated with poor prognosis in primary gastric cancer., PMID:24913813
A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer., PMID:24516561
Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours., PMID:24265292
Genome-wide analysis of DNA methylation in tongue squamous cell carcinoma., PMID:23446731
Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening., PMID:23320751
A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis., PMID:23133512
Functional annotation of the human fat cell secretome., PMID:22616691
Involvement of ITIH5, a candidate gene for congenital uterovaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome), in female genital tract development., PMID:23539898
Clinical utility gene card for: Mayer-Rokitansky-Küster-Hauser syndrome., PMID:21897448
ITIH-5 expression in human adipose tissue is increased in obesity., PMID:21852814
Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models., PMID:21139803
For research use only. Not for human or drug use.
