Catalog No.
YHH98701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp426-Glu599
Predicted molecular weight
20.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5D1E8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1
Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA., PMID:40460118
Long Noncoding RNAs Papillary Thyroid Carcinoma Susceptibility Candidate 3 Antisense 1 and Papillary Thyroid Carcinoma Susceptibility Candidate 3 Synergistically Regulate ZC3H12A mRNA Stability via Vimentin at 14q13.3 Thyroid Cancer Locus., PMID:40376726
The RNA-Binding Proteins MCPIP2 and IGF2BP1 Competitively Modulate Breast Tumor Angiogenesis by Antagonizing VEGFA mRNA Stability and Expression., PMID:40354028
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells., PMID:40327039
TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy., PMID:40238115
MCPIP3 orchestrates the balance of epidermal proliferation and differentiation., PMID:40200325
Transmembrane TNF-α Reverse Signaling Alleviates Lipopolysaccharide-induced Inflammation by Regulating the MCPIP1/SIRT1/NF-κB Pathway., PMID:40147866
A Novel Missense Variant of ZC3H12A in Pulmonary Arterial Hypertension., PMID:40066211
Glycocalyx hyaluronan removal-induced increasing of cell stiffness delays breast cancer cells progression., PMID:40011237
Targeting the IL-17A pathway for therapy in early-stage tendinopathy., PMID:39988349
P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset., PMID:39957192
The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis., PMID:39815326
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6., PMID:39661293
Transcriptome-wide identification and analysis reveals m6A regulation of metabolic reprogramming in shrimp (Marsupenaeus japonicus) under virus infection., PMID:39563253
Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora., PMID:39513620
MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomas., PMID:39428471
MCPIP1 Elicits a Therapeutic Effect on Cervical Cancer by Facilitating XIAP mRNA Decay via Its Endoribonuclease Activity., PMID:39408613
HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression., PMID:39292108
Crystal structure of NYN domain of Human KHNYN in complex with single strand RNA., PMID:39167961
Keratinocyte and myeloid MCPIP1 have distinct roles in maintaining skin homeostasis., PMID:39032853
Inflammatory response of leptomeninges to a single cortical spreading depolarization., PMID:39009958
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression., PMID:38830770
A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice., PMID:38802511
A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions., PMID:38737277
Regnase-1 D141N mutation induces CD4+ T cell-mediated lung granuloma formation via upregulation of Pim2., PMID:38700370
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells., PMID:38498096
Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling., PMID:38470486
ZC3H12A inhibits tumor growth and metastasis of breast cancer under hypoxic condition via the inactivation of IL-17 signaling pathway., PMID:38357935
Metformin Protects Against Acute Kidney Injury Induced by Lipopolysaccharide via Up-Regulating the MCPIP1/SIRT1 Pathway., PMID:38345758
MCPIP1 Inhibits Hepatic Stellate Cell Activation in Autocrine and Paracrine Manners, Preventing Liver Fibrosis., PMID:38311169
Lung Epithelial Regnase-1 Dampens Local Immune Response but Does Not Worsen Susceptibility to Klebsiella pneumoniae., PMID:38226923
Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies., PMID:38200556
MCPIP1 Controls the Effects of Myeloid Cells on Skin Carcinogenesis and Hair Growth., PMID:38154560
Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma., PMID:38007161
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation., PMID:37975259
Hepatic Mcpip1 regulates adaptation to food restriction in mice., PMID:37929720
Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity., PMID:37814340
Neuroprotective Effects of Melittin Against Cerebral Ischemia and Inflammatory Injury via Upregulation of MCPIP1 to Suppress NF-κB Activation In Vivo and In Vitro., PMID:37812268
MCPIP1 functions as a safeguard of early embryonic development., PMID:37805647
MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice., PMID:37689231
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes., PMID:37644339
Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas., PMID:37623434
LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer., PMID:37519886
Depletion of Mcpip1 in murine myeloid cells results in intestinal dysbiosis followed by allergic inflammation., PMID:37257731
miR-143-3p shuttled by M2 macrophage-derived extracellular vesicles induces progression of colorectal cancer through a ZC3H12A/C/EBPβ axis-dependent mechanism., PMID:37126984
Analysis of differential gene immune infiltration and clinical characteristics of skin cutaneous melanoma based on systems biology and drug repositioning methods to identify drug candidates for skin cutaneous melanoma., PMID:37086280
MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis., PMID:37015751
Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1)., PMID:37010640
LncRNA LITATS1 suppresses TGF-β-induced EMT and cancer cell plasticity by potentiating TβRI degradation., PMID:36994542
The homeostatic function of Regnase-2 restricts neuroinflammation., PMID:36753401
For research use only. Not for human or drug use.
