Catalog No.
YHH26901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val725-Phe874
Predicted molecular weight
19.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16512
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C-like PKN, Serine/threonine-protein kinase N1, PRK1, Serine-threonine protein kinase N, PKN, Protease-activated kinase 1, PRKCL1, PKN1, Protein-kinase C-related kinase 1, PAK-1, Protein kinase PKN-alpha, PAK1, Protein kinase C-like 1
Unresolved Issues in Familial Mediterranean Fever: Is p.R202Q MEFV Variant Potentially Pathogenetic in Unleashing Inflammation?, PMID:40493122
Deepening the Modulatory Activity of Bioactive Compounds Against AFB1- and OTA-Induced Neuronal Toxicity Through a Proteomic Approach., PMID:40427453
Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N., PMID:39843538
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression., PMID:39779823
Epidermal stem cell-derived exosomes improve wound healing by promoting the proliferation and migration of human skin fibroblasts., PMID:39687464
PKN2 Promotes Peripheral Nerve Repair by Regulating Autophagy via Activation of the AKT-mTOR Pathway: An In Vitro Study., PMID:39575558
PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State., PMID:39560431
Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models., PMID:39332493
Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion., PMID:39266515
Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds., PMID:39002682
Role of PKN1 in Retinal Cell Type Formation., PMID:38474095
Rapid depletion of target proteins in plants by an inducible protein degradation system., PMID:38446628
Lipid-Binding Regions within PKC-Related Serine/Threonine Protein Kinase N1 (PKN1) Required for Its Regulation., PMID:38441874
A quantitative proteomic study reveals oxidative stress and synapse-related proteins contributed to TDCIPP exposure induced neurotoxicity., PMID:38262093
The pyrin inflammasome, a leading actor in pediatric autoinflammatory diseases., PMID:38250061
Protein Kinase N1 Level Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery: A Prospective Cohort Study., PMID:38228111
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis., PMID:38092754
PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic-Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling., PMID:38002281
F-actin nanostructures rearrangements and regulation are essential for SARS-CoV-2 particle production in host pulmonary cells., PMID:37564698
The role of PKN1 in glioma pathogenesis and the antiglioma effect of raloxifene targeting PKN1., PMID:37480215
PKN1 Kinase: A Key Player in Adipocyte Differentiation and Glucose Metabolism., PMID:37242297
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration., PMID:36897022
Molecular mechanism of Ganji Fang in the treatment of hepatocellular carcinoma based on network pharmacology, molecular docking and experimental verification technology., PMID:36744264
ANP promotes HTR-8/SVneo cell invasion by upregulating protein kinase N 3 via autophagy inhibition., PMID:36723798
Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertension., PMID:36531719
Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division., PMID:36423220
Target protein identification of andrographolide based on isomer approach., PMID:36279844
The Influence of Different γ-Irradiation Patterns on Factors that May Affect Cell Cycle Progression in Male Rats., PMID:35982824
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance., PMID:35895078
Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover., PMID:35809565
Efficient delivery of PKN3 shRNA for the treatment of breast cancer via lipid nanoparticles., PMID:35752145
Epirubicin Alters DNA Methylation Profiles Related to Cardiotoxicity., PMID:35748249
Screening of Specific and Common Pathways in Breast Cancer Cell Lines MCF-7 and MDA-MB-231 Treated with Chlorophyllides Composites., PMID:35745070
Multifunctional Lipid Nanoparticles for Protein Kinase N3 shRNA Delivery and Prostate Cancer Therapy., PMID:35731922
PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses., PMID:35730579
DIFFERENTIAL EXPRESSION PATTERN OF AIP, UCKL1, AND PKN1 GENES IN PROSTATE CANCER PATIENTS., PMID:35548962
Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer., PMID:35533253
Discovery of new PKN2 inhibitory chemotypes via QSAR-guided selection of docking-based pharmacophores., PMID:35507210
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery., PMID:35104640
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion., PMID:35081338
Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice., PMID:35028715
Differential expression patterns of AIP, UCKL1, and PKN1 genes in breast cancer of different molecular subtypes., PMID:34967537
Genomic and phenotypic analysis of SspH1 identifies a new Salmonella effector, SspH3., PMID:34942035
Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease., PMID:34905657
Protein kinase N2 connects blood flow with NO production in a double AKT., PMID:34720094
Gasdermin D in pyroptosis., PMID:34589396
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia., PMID:34589290
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation., PMID:34499618
Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice., PMID:34312179
Protein kinase N1 promotes proliferation and invasion of liver cancer., PMID:33968181
For research use only. Not for human or drug use.
