Catalog No.
YHH08501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg53-His516
Predicted molecular weight
56.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15392
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0018, DHCR24, 24-dehydrocholesterol reductase, Seladin-1, 3-beta-hydroxysterol Delta-24-reductase, Diminuto/dwarf1 homolog, Delta(24)-sterol reductase
Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats., PMID:40472616
Identification of Differentially Expressed Genes in Spinal Cord Injury., PMID:40428335
Identification of Fatty Acid Metabolism Disorder-Related Gene Signature in Septic Cardiomyopathy., PMID:40406682
Transcriptomic analysis reveals sexual dimorphism in lipid metabolism within largemouth bass (Micropterus salmoides) fed the high-fat diet., PMID:40373386
Proteome-Wide Covalent Targeting of Acidic Residues with Tunable N-Aryl Aziridines., PMID:40343844
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer., PMID:40287115
3β-hydroxysteroid-Δ24 reductase integrates cholesterol metabolism and innate immune to promote PRRSV replication., PMID:40203946
Changes in rat plasma proteomes during the first week after birth., PMID:40070918
Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway., PMID:39862102
24-Dehydrocholesterol Reductase Facilitates Cisplatin Resistance of Non-small Cell Lung Cancer via Repressing Reactive Oxygen Species/Ferroptosis Pathway., PMID:39830660
High mRNA Expression of 24 Dehydrocholesterol Reductase (DHCR24) in the Treatment of Doxorubicin-Induced Heart Failure in Rats., PMID:39796168
Dysregulation of Brain Cholesterol Biosynthetic Pathway following Hypoxia Ischemia in Neonatal Mice., PMID:39709952
A study on the functional role of the DHCR24 gene in gonadal differentiation and development of Macrobrachium nipponense., PMID:39604403
Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients., PMID:39578712
Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24., PMID:39552565
Integrating multiomics sequencing analyses uncover the key mechanisms related to oxidative stress, mitochondria, and immune cells in keloid., PMID:39489224
Perfluorooctane sulfonate (PFOS) and benzo[a]pyrene (BaP) synergistically induce neurotoxicity in C6 rat glioma cells via the activation of neurotransmitter and Cyp1a1-mediated steroid hormone synthesis pathways., PMID:39423996
The Systemic Effect of Ischemia Training and Its Impact on Bone Marrow-Derived Monocytes., PMID:39404366
Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers., PMID:39334355
In vivo functional analysis of the cotton bollworm Helicoverpa armigera 24-dehydrocholesterol reductase (HaDHCR24) in phytosterol metabolism., PMID:38973264
Engineering sub-organelles of a diploid Saccharomyces cerevisiae to enhance the production of 7-dehydrocholesterol., PMID:38936763
Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice., PMID:38895818
DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review., PMID:38847653
Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol., PMID:38775844
[Uncovering the molecular mechanisms behind steroidal saponin accumulation in Liriope muscari (Decne.) Baily through transcriptome sequencing and bioinformatics analysis]., PMID:38658153
TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia., PMID:38649789
Identification of novel molecules and pathways associated with fascin actin‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis., PMID:38426543
DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling., PMID:38407305
A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells., PMID:38365720
Distinctive genes and signaling pathways associated with type 2 diabetes-related periodontitis: Preliminary study., PMID:38241313
Exploiting in silico structural analysis to introduce emerging genotype-phenotype correlations in DHCR24-related sterol biosynthesis disorder: a case study., PMID:38239854
Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin., PMID:38133877
3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING., PMID:38032198
SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer., PMID:37991737
Multiple-microarray analysis for identification of key genes involved in diabetic nephropathy., PMID:37986381
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus., PMID:37891690
Integrated transcriptomic and proteomic analyses reveal the mechanism of easy acceptance of artificial pelleted diets during food habit domestication in Largemouth bass (Micropterus salmoides)., PMID:37891233
Control Phytophagous Nematodes By Engineering Phytosterol Dealkylation Caenorhabditis elegans as a Model., PMID:37843756
Impact of Cholesterol Metabolism on H2O2-Induced Oxidative Stress Injury in HepG2 Cells Treated with Fatty Acids., PMID:37820665
Integrated multi-omics and machine learning approach reveals lipid metabolic biomarkers and signaling in age-related meibomian gland dysfunction., PMID:37675286
The Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis., PMID:37509850
High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24)., PMID:37458798
Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?, PMID:37447330
Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum., PMID:37446179
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation., PMID:37357756
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice., PMID:37344916
Dietary Cholesterol Supplementation Inhibits the Steroid Biosynthesis but Does Not Affect the Cholesterol Transport in Two Marine Teleosts: A Hepatic Transcriptome Study., PMID:37312679
"MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression"., PMID:37086967
Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific., PMID:37047376
Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization., PMID:37011864
For research use only. Not for human or drug use.
