Catalog No.
YHG89201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp295
Predicted molecular weight
35.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14749
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GNMT, Glycine N-methyltransferase
Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice., PMID:40415790
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
The complex role of glycine N-methyltransferase in metabolism-a review., PMID:40025311
Consumption of Endogenous Caspase-3 Activates Molecular Theranostic Nanoplatform against Inflammation-Induced Profibrotic Positive Feedback in Pulmonary Fibrosis., PMID:39686776
Structural Insights into the Mechanism of a Polyketide Synthase Thiocysteine Lyase Domain., PMID:39546807
Identification of senescence related hub genes and potential therapeutic compounds for dilated cardiomyopathy via comprehensive transcriptome analysis., PMID:39029429
Brucine Suppresses Malignant Progression of Prostate Cancer by Decreasing Sarcosine Accumulation via Downregulation of GNMT in the Glycine/sarcosine Metabolic Pathway., PMID:38877335
Transcriptional control of a metabolic switch regulating cellular methylation reactions is part of a common response to stress in divergent bee species., PMID:38736357
Identifying the Crucial Biomarker of MASH-Related HCC., PMID:38726780
Parental betaine supplementation promotes gosling growth with epigenetic modulation of IGF gene family in the liver., PMID:38483185
The Role of GNMT and MMP12 Expression in Determining TACE Efficacy: Validation at Transcription and Protein Levels., PMID:38250306
Excessive Substitution of Fish Meal with Fermented Soybean Meal Induces Oxidative Stress by Impairing Glutathione Metabolism in Largemouth Bass (Micropterus salmoides)., PMID:38136216
Identification and validation of molecular subtypes and a 9-gene risk model for breast cancer., PMID:37747033
A novel telomere-related gene prognostic signature for survival and drug treatment efficiency prediction in lung adenocarcinoma., PMID:37589509
Translocation of Methionine Adenosyl Transferase MAT2A and Its Prognostic Relevance for Liver Hepatocellular Carcinoma., PMID:37240447
Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase., PMID:37047834
A new view on functions of the lysine demalonylase activity of SIRT5., PMID:36921688
Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models., PMID:36810287
Hepatic oleate regulates one-carbon metabolism during high carbohydrate feeding., PMID:36791500
Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase., PMID:36077467
Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice., PMID:35682942
Duodenal Metabolic Profile Changes in Heat-Stressed Broilers., PMID:35681802
Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress., PMID:35216100
Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis., PMID:35008908
Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD., PMID:34859106
Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase., PMID:34649149
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology., PMID:34135558
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis., PMID:34132534
MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients., PMID:34065390
Interaction analysis of gene variants related to one-carbon metabolism with chronic hepatitis B infection in Chinese patients., PMID:33894044
Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging., PMID:33807010
Duodenal-jejunal bypass maintains hepatic S-adenosylmethionine/S-homocysteine ratio in diet-induced obese rats., PMID:33753007
Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling., PMID:33723074
Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma., PMID:33718182
Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis., PMID:33714108
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification., PMID:33510167
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis., PMID:33241846
Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function., PMID:32951289
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice., PMID:32908189
Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH., PMID:32768187
Proteomic changes by radio-mitigative thrombopoietin receptor agonist romiplostim in the blood of mice exposed to lethal total-body irradiation., PMID:32602419
Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA., PMID:32415241
Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana., PMID:32290267
Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways., PMID:32169759
Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes., PMID:32145700
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production., PMID:31721422
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease., PMID:31668391
Lower methionine/cystine ratio in low-protein diet improves animal reproductive performance by modulating methionine cycle., PMID:31572580
Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice., PMID:31470507
Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma., PMID:31277598
For research use only. Not for human or drug use.
