Catalog No.
YHG58201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val183-Ala482
Predicted molecular weight
36.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13547
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone deacetylase 1, HDAC1, RPD3L1, HD1
Mechanism of Ginsenosides in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking., PMID:40508108
Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder., PMID:40504297
The Splicing Factor PTBP1 interacts with RUNX1 and is Required for Leukemia Cell Survival., PMID:40475655
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection., PMID:40464916
Loss of negative regulation by HDAC1 and REST contributes to MAD1 overexpression in breast cancer., PMID:40464797
Dual Targeting EZH2 and Histone Deacetylases in Human Uterine Sarcoma Cells Under Both 2D and 3D Culture Conditions., PMID:40464712
Gastrointestinal exposure to silica nanoparticles induced Alzheimer's disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC., PMID:40457432
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes., PMID:40446041
PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation., PMID:40408476
Protein Acetylation in Age-Related Macular Degeneration: Mechanisms, Roles, and Therapeutic Perspectives., PMID:40402519
Honokiol in the treatment of triple-negative breast cancer: a network pharmacology approach and experimental validation., PMID:40398092
Identification of Hub Genes and Pathways Associated with Ageing in Diabetic Encephalopathy Based on Transcriptome Analysis., PMID:40397335
Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression., PMID:40394764
Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment., PMID:40383016
Structural Optimization of 1,3-Diaryl-1,2,4-triazole-Capped Histone Deacetylase 6 Inhibitors to Obtain Novel Antiesophageal Cancer Candidates., PMID:40382720
Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors., PMID:40370107
Dehydrozingerone ameliorates renal structure compromised in diabetic nephropathy., PMID:40345456
Hdac1 as an early determinant of intermediate-exhausted CD8+ T cell fate in chronic viral infection., PMID:40333757
Protective Effects of Rat Bone Marrow Mesenchymal Stem Cells-Derived Fusogenic Plasma Membrane Vesicles Containing VSVG Protein Mediated Mitochondrial Transfer on Myocardial Injury In Vitro., PMID:40330432
PKG-Mediated Phosphorylation of TOP2A Activates HDAC to Drive Photoreceptor Cell Death in rd1 Mouse Inherited Retinal Degeneration., PMID:40320856
Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression., PMID:40319261
HDAC1 is involved in the destabilization of the HSF2 protein under nonstress and stress conditions., PMID:40318841
14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation., PMID:40306359
Dual GSK-3β/HDAC Inhibitors Enhance the Efficacy of Macrophages to Control Mycobacterium tuberculosis Infection., PMID:40305296
PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1., PMID:40301306
Discovery of hydrazide-based PI3K/HDAC dual inhibitors with enhanced pro-apoptotic activity in lymphoma cells., PMID:40300459
IPMK depletion influences genome-wide DNA methylation., PMID:40300331
Cytokine and epigenetic regulation of CEACAM6 mediates EGFR-driven signaling and drug response in lung adenocarcinoma., PMID:40263546
Magnesium-based implants accelerate femoral fracture healing through promoting histone lactylation-mediated osteoclastogenesis inhibition., PMID:40252757
Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation., PMID:40252366
In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1., PMID:40251368
Identification and validation of crotonylation-related diagnostic markers for lung adenocarcinoma via weighted correlation network analysis and machine learning., PMID:40248736
Tissue engineering with targeted delivery of nanotized S-nitrosyl mutant of NEMO ameliorates myocardial infarction., PMID:40235354
Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation., PMID:40234449
Kolmogorov-Arnold networks for predicting drug-gene associations of HDAC1 inhibitors in periodontitis., PMID:40233475
Acetylation-regulated DUSP1 deficiency contributes to renal fibrosis progression., PMID:40213676
Analysis of differentially expressed genes in schizophrenia based on bioinformatics and corresponding mRNA expression levels., PMID:40209528
RNA binding motif protein 25 is a negative prognostic biomarker and promotes cell proliferation via alternative splicing in hepatocellular carcinoma., PMID:40186887
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis., PMID:40176744
c-Ski is a novel repressor of NF-κB through interaction with p65 and HDAC1 in U937 cells., PMID:40176138
Rutin ameliorates stress-induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin-5 axis., PMID:40176114
Reversal of epithelial to mesenchymal transition in triple negative breast cancer through epigenetic modulations by dietary flavonoid Galangin and its combination with SAHA., PMID:40176095
HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy., PMID:40175628
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment., PMID:40175372
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique., PMID:40171441
Synthesis and biological evaluation of novel 4-Arylaminoquinolines derivatives as EGFR/HDAC inhibitors., PMID:40164393
Protein post-translational modification crotonylation of TXN and GLO1 in artery and vein grafts for coronary artery surgery., PMID:40138913
HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis., PMID:40131574
The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors., PMID:40128216
DUBR non-coding RNA regulates gene expression by affecting AP-1 enhancer accessibility., PMID:40117000
For research use only. Not for human or drug use.
