Catalog No.
DHH72402
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, VSIG9, V-set and immunoglobulin domain-containing protein 9, T-cell immunoreceptor with Ig and ITIM domains
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q495A1
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
OMP-313M32, CAS: 2044984-83-8
Clone ID
Etigilimab
Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors. PMID: 32849489
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer. PMID: 34367161
Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes. PMID: 31108170
Dynamics of TIGIT and PD-1 expression on NK cells during the course of normal pregnancy. PMID: 33359535
[Research Advance of Immune Checkpoint Molecule TIGIT in Hematological Malignancies--Review]. PMID: 34105506
Targeting PVR (CD155) and its receptors in anti-tumor therapy. PMID: 30275538
Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency. PMID: 32397769
Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia. PMID: 32764229
Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis. PMID: 29890552
Use of aspirin in the prevention of colorectal cancer through TIGIT-CD155 pathway. PMID: 31090213
Cancer biomarkers for targeted therapy. PMID: 31807308
TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT. PMID: 29648914
Phage display screening of TIGIT-specific antibody for antitumor immunotherapy. PMID: 31094670
Targeting novel inhibitory receptors in cancer immunotherapy. PMID: 33288379
Nectin-2 Expression on Malignant Plasma Cells Is Associated with Better Response to TIGIT Blockade in Multiple Myeloma. PMID: 32513837
TIGIT-Fc Promotes Antitumor Immunity. PMID: 34244300
Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus. PMID: 31938353
Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR. PMID: 32894141
Expression of the immune checkpoint receptor TIGIT in Hodgkin's lymphoma. PMID: 30514251
Immunotherapy for Multiple Myeloma. PMID: 31842518
Monitoring TIGIT/DNAM-1 and PVR/PVRL2 Immune Checkpoint Expression Levels in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia. PMID: 30639819
TIGIT(+) iTregs elicited by human regulatory macrophages control T cell immunity. PMID: 30030423
Combined evaluation of the expression status of CD155 and TIGIT plays an important role in the prognosis of LUAD (lung adenocarcinoma). PMID: 31954274
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease. PMID: 27016609
Increased Expression of TIGIT/CD57 in Peripheral Blood/Bone Marrow NK Cells in Patients with Chronic Myeloid Leukemia. PMID: 33102599
Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma. PMID: 32461587
TIGIT negatively regulates inflammation by altering macrophage phenotype. PMID: 26307002
Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells. PMID: 28138156
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. PMID: 30659054
Mechanisms of failure of chimeric antigen receptor T-cell therapy. PMID: 31577606
Prognostic value of immune checkpoint molecules in breast cancer. PMID: 32602545
TIGIT signalling pathway negatively regulates CD4(+) T-cell responses in systemic lupus erythematosus. PMID: 28108989
TIGIT/PVR and LncRNA ANRIL dual-targetable PAMAM polymeric nanoparticles efficiently inhibited the hepatoma carcinoma by combination of immunotherapy and gene therapy. PMID: 33480288
Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease. PMID: 33936071
Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model. PMID: 31410870
Targeting the TIGIT-PVR immune checkpoint axis as novel therapeutic option in breast cancer. PMID: 31741778
CD155 immunoregulation as a target for natural killer cell immunotherapy in glioblastoma. PMID: 32532329
Publisher Correction: Antibody engineers seek optimal drug targeting TIGIT checkpoint. PMID: 32999474
MEG3 modulates TIGIT expression and CD4 + T cell activation through absorbing miR-23a. PMID: 30382432
TIGIT and CD155 as Immune-Modulator Receptor and Ligand on CD4(+) T cells in Preeclampsia Patients. PMID: 33855917
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. PMID: 29296521
Construction and characterization of recombinant adenovirus carrying a mouse TIGIT-GFP gene. PMID: 26782515
Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals. PMID: 30364127
Targeting TIGIT for Immunotherapy of Cancer: Update on Clinical Development. PMID: 34572463
Contribution of inhibitory receptor TIGIT to NK cell education. PMID: 28438433
Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells. PMID: 29359507
TIGIT-positive circulating follicular helper T cells and sickle cell alloimmunization. PMID: 26521294
Frequencies of circulating regulatory TIGIT(+)CD38(+) effector T cells correlate with the course of inflammatory bowel disease. PMID: 30127383
For research use only. Not for human or drug use.
