Catalog No.
DHH72401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, VSIG9, V-set and immunoglobulin domain-containing protein 9, T-cell immunoreceptor with Ig and ITIM domains
Concentration
2.6 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q495A1
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MTIG-7192-A, MTIG-7192A, MTIG7192A, RG-6058, RO-7092284, RO7092284, CAS: 1918185-84-8
Clone ID
Tiragolumab
Tiragolumab Impresses in Multiple Trials, PMID: 32576590
ASCO 2020 non-small lung cancer (NSCLC) personal highlights, PMID: 33456617
Advances in the management of non-small cell lung cancer (NSCLC): A new practice changing data from asco 2020 annual meeting, PMID: 33271494
TIGIT/CD226 Axis Regulates Anti-Tumor Immunity, PMID: 33670993
A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function. PMID: 31500665
TIGIT/CD226 Axis Regulates Anti-Tumor Immunity. PMID: 33670993
TIGIT checkpoint inhibition for myeloma. PMID: 30337318
PET Imaging of TIGIT Expression on Tumor-Infiltrating Lymphocytes. PMID: 33408249
Enhanced expression of TIGIT but not neuropilin-1 in patients with type 2 diabetes mellitus. PMID: 32540486
Human TIGIT on porcine aortic endothelial cells suppresses xenogeneic macrophage-mediated cytotoxicity. PMID: 31402149
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells. PMID: 32028328
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. PMID: 33303760
Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3, and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study. PMID: 33000173
The Inhibitory PVRL1/PVR/TIGIT Axis in Immune Therapy for Hepatocellular Carcinoma. PMID: 32574623
A Cross-Species Reactive TIGIT-Blocking Antibody Fc Dependently Confers Potent Antitumor Effects. PMID: 32887749
Recovery of CD226-TIGIT(+)FoxP3(+) and CD226-TIGIT-FoxP3(+) regulatory T cells contributes to clinical remission from active stage in ulcerative colitis patients. PMID: 31883787
TIGIT expression is upregulated in T cells and causes T cell dysfunction independent of PD-1 and Tim-3 in adult B lineage acute lymphoblastic leukemia. PMID: 31376919
TOX is a critical regulator of tumour-specific T cell differentiation. PMID: 31207604
Characteristic of TIGIT and DNAM-1 Expression on Foxp3+ gammadelta T Cells in AML Patients. PMID: 32802845
DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. PMID: 30081950
Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups. PMID: 31611702
Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis. PMID: 32793241
Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity. PMID: 32503945
Expression of the immune checkpoint receptor TIGIT in seminoma. PMID: 31423216
CD226 opposes TIGIT to disrupt Tregs in melanoma. PMID: 30046006
The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies. PMID: 28035916
Dysfunctional role of elevated TIGIT expression on T cells in oral squamous cell carcinoma patients. PMID: 33125794
Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS. PMID: 32269065
Targeting NK-cell checkpoints for cancer immunotherapy. PMID: 28236750
Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation. PMID: 32668241
Effective Anti-tumor Response by TIGIT Blockade Associated With FcgammaR Engagement and Myeloid Cell Activation. PMID: 33117369
NK Cell Dysfunction and Checkpoint Immunotherapy. PMID: 31552017
[Study on role of TIGIT signal in Th1/Th2 balance in Schistosoma japonicum-infected mice]. PMID: 29770653
Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer. PMID: 30132062
TIGIT(+) A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. PMID: 32201225
TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasis. PMID: 29512851
Antibody engineers seek optimal drug targeting TIGIT checkpoint. PMID: 32887966
TIGIT-Fc alleviates acute graft-versus-host disease by suppressing CTL activation via promoting the generation of immunoregulatory dendritic cells. PMID: 29960041
Tiragolumab Impresses in Multiple Trials. PMID: 32576590
Control of Regulatory T Cells by Co-signal Molecules. PMID: 31758535
Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis. PMID: 33413573
Balancing natural killer cell activation through paired receptors. PMID: 25743219
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma. PMID: 30659053
CD155, an onco-immunologic molecule in human tumors. PMID: 28730595
For research use only. Not for human or drug use.
