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Research Grade Pexelizumab (DHB90007)

Host species:Humanized
Isotype:scFv-nd-nd
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHB90007

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

scFv-nd-nd

Clonality

Monoclonal

Target

CPAMD4, C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01031

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

5G1.1-SC, CAS: 219685-93-5

Clone ID

Pexelizumab

Data Image
References

Pexelizumab Alexion, PMID: 12137406

Pexelizumab and its role in the treatment of myocardial infarction and in coronary artery bypass graft surgery: a review, PMID: 18537766

Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients, PMID: 18954626

Pexelizumab, an Anti-C5 Complement Antibody for Primary Coronary Revascularization: A New Insight from Old Versions, PMID: 22044037

Pexelizumab: a novel therapy for myocardial ischemia-reperfusion, PMID: 15883613

Pexelizumab and survival in cardiac surgery, PMID: 23439772

Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial, PMID: 12925454

Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial, PMID: 17200474

Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial, PMID: 20129531

Pexelizumab does not "complement" percutaneous coronary intervention in patients with ST-elevation myocardial infarction, PMID: 17200480

Pexelizumab and the APEX AMI trial, PMID: 17473297

Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients, PMID: 16863750

Effect of pexelizumab in coronary artery bypass graft surgery with extended aortic cross-clamp time, PMID: 16928483

Concerning the mechanism of pexelizumab's benefit in acute myocardial infarction, PMID: 16569534

Pexelizumab -- a C5 complement inhibitor for use in both acute myocardial infarction and cardiac surgery with cardiopulmonary bypass, PMID: 15952913

Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials, PMID: 20880552

Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial, PMID: 22795281

Inhibition of complement activation by pexelizumab reduces death in patients undergoing combined aortic valve replacement and coronary artery bypass surgery, PMID: 16434264

Myocardial infarct size reduction with pexelizumab: the role of chance is patently clear, PMID: 20129532

Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery, PMID: 15331798

Pexelizumab may be hazardous to those with ST-segment elevation myocardial infarction undergoing primary percutaneous interventions without using glycoprotein IIb-IIIa inhibitors, PMID: 21109318

Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview, PMID: 16875911

Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial, PMID: 15150203

Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction: the COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) trial, PMID: 12925455

Pharmacologic C5-complement suppression reduces blood loss during on-pump cardiac surgery, PMID: 15673408

Impact of pexelizumab, an anti-C5 complement antibody, on total mortality and adverse cardiovascular outcomes in cardiac surgical patients undergoing cardiopulmonary bypass, PMID: 14992903

Prognostic significance of blood markers of inflammation in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty and effects of pexelizumab, a C5 inhibitor: a substudy of the COMMA trial, PMID: 15872036

A critical appraisal of pexelizumab treatment in patients undergoing coronary artery bypass grafting, PMID: 21763876

Cardiogenic shock and heart failure post-percutaneous coronary intervention in ST-elevation myocardial infarction: observations from "Assessment of Pexelizumab in Acute Myocardial Infarction", PMID: 21742094

Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial, PMID: 23194495

Eculizumab (Alexion), PMID: 12186261

Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI): a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention, PMID: 15864228

Do baseline atrial electrocardiographic and infarction patterns predict new-onset atrial fibrillation after ST-elevation myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial, PMID: 20444469

Mortality implications of primary percutaneous coronary intervention treatment delays: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial, PMID: 21304097

A model for predicting mortality in acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: results from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial, PMID: 20858863

Variations in practice and outcomes in patients undergoing primary percutaneous coronary intervention in the United States and Canada: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI) trial, PMID: 22607857

Is visual interpretation of coronary epicardial flow reliable in patients with ST-elevation myocardial infarction undergoing primary angioplasty? Insights from the angiographic substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial, PMID: 20435202

Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial, PMID: 23351826

Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial, PMID: 20934561

Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: An Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Substudy, PMID: 20691832

Prognostic implications of left ventricular end-diastolic pressure during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Findings from the Assessment of Pexelizumab in Acute Myocardial Infarction study, PMID: 24176448

Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial, PMID: 19853693

Why did the anti-C5 complement antibody pexelizumab not reduce infarct size but influence clinical outcomes positively when applied as adjunctive therapy to primary percutaneous coronary intervention?, PMID: 15117866

The pathogenesis of rheumatoid arthritis, PMID: 17121483

ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial, PMID: 18779444

Inflammatory response to cardiopulmonary bypass, PMID: 12607717

Influence of Clinical Trials of Acute Coronary Syndrome Beyond the Primary Hypothesis: A Systematic Review, PMID: 32745162

Innate immunity-mediated allograft rejection and strategies to prevent it, PMID: 17445569

Predictors, moderators and mediators for the effectiveness of pexelizumab treatment in patients undergoing primary coronary revascularization, PMID: 21242011

On the value of therapeutic interventions targeting the complement system in acute myocardial infarction, PMID: 27810412

Datasheet

Document Download

Research Grade Pexelizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Pexelizumab [DHB90007]
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