Catalog No.
YHE72101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr420
Predicted molecular weight
49.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49841
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glycogen synthase kinase-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, GSK-3 beta
Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer., PMID:40506749
Avenanthramide-C as Alzheimer's Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models., PMID:40498003
Exploration of Asparagus racemosus Willd for Alzheimer's Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein., PMID:40483633
Low-Dose Intranasal Metformin Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease., PMID:40478515
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5-Mediated GSK-3β/c-Myc Signaling Pathway., PMID:40476323
Case-control study combined with machine learning techniques to identify key genetic variations in GSK3B that affect susceptibility to diabetic kidney diseases., PMID:40474205
Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint., PMID:40474025
A novel pThr217 tau monoclonal antibody reveals neuropathological heterogeneity in tauopathies., PMID:40473739
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis., PMID:40468463
Hepatocyte Growth Factor-Modified Dental Pulp Stem Cells Potentially Regulate Novel Renal Fibrosis-Associated Gene via PI3K/AKT/GSK3β Pathway to Alleviate Renal Fibrosis., PMID:40462757
[Mechanism of matrine against senescence in human umbilical vein endothelial cells based on network pharmacology and experimental verification]., PMID:40461235
OTUD1 inhibits macrophage ferroptosis via regulation of AMPK and GSK3β/β-catenin signaling pathways exerting protective effects in sepsis-induced acute lung injury., PMID:40460602
Hypothermia Alleviates TBI-Induced Tau Hyperphosphorylation Through RBM3-Dependent GSK-3β and AMPK Pathways., PMID:40457153
Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress., PMID:40449843
Exosome-derived SLC12A2-DT promotes macrophage M2 polarization-mediated hepatocellular carcinoma progression., PMID:40446695
Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer's disease., PMID:40443428
Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity., PMID:40438591
Pedunculoside regulates the differentiation of neural stem cells into neurons via the PI3K/AKT/GSK-3β pathway., PMID:40436489
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway., PMID:40436074
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease., PMID:40435831
Therapeutic role of Crateva religiosa in diabetic nephropathy: Insights into key signaling pathways., PMID:40435181
Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates., PMID:40434714
Exploring the Neuroprotective Properties of Celery (Apium graveolens Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease., PMID:40430359
Protective Effects of Lotus Seedpod Extract on Hepatic Lipid and Glucose Metabolism via AMPK-Associated Mechanisms in a Mouse Model of Metabolic Syndrome and Oleic Acid-Induced HepG2 Cells., PMID:40427477
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance., PMID:40424469
Androgen receptor plays critical role in regulating cervical cancer cell migration., PMID:40409531
Stress exposure affects amyotrophic lateral sclerosis pathogenesis via PI3K/Akt and focal adhesion pathways: evidence from three experimental models., PMID:40399476
Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition., PMID:40398622
[Effect of electroacupuncture on the permeability of blood-brain-barrier mediated by Wnt7a/β-catenin/GSK-3β pathway in mice with Parkinson's disease]., PMID:40390615
A Selective GSK3β Inhibitor, Tideglusib, Decreases Intermittent Access and Binge Ethanol Self-Administration in C57BL/6J Mice., PMID:40390305
Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization., PMID:40382817
AHNAK2 confers 5-fluorouracil resistance in colorectal cancer via activation of the AKT/GSK-3β signaling axis., PMID:40382757
The function of β-catenin and GSK-3β in Procambarus clarkii Wnt signaling pathway during Spiroplasma eriocheiris infection., PMID:40381786
Limettin and PD98059 Mitigated Alzheimer's Disease Like Pathology Induced by Streptozotocin in Mouse Model: Role of p-ERK1/2/p-GSK-3β/p-CREB/BDNF Pathway., PMID:40381124
DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway., PMID:40380281
Swietenine improved the progression of diabetic nephropathy through inhibiting ferroptosis via activating Akt/GSK-3β/Nrf2 signaling pathway., PMID:40378934
Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK-3β Signaling., PMID:40377174
Ergothioneine Suppresses Amyloid β-Induced Tau Phosphorylation and Cytotoxicity by Inactivating Glycogen Synthase Kinase-3β in Cultured Neurons., PMID:40370244
Fyn-dependent Tau microcluster formation seeds and boosts extensive Tau pathology., PMID:40366450
Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation., PMID:40365863
Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in PLGA Nanoparticles., PMID:40362470
Phillyrin for sepsis-related acute lung injury: A potential strategy suppressing GSK-3β., PMID:40359720
Exploring the therapeutic potential and in vitro validation of baicalin for the treatment of triple-negative breast cancer., PMID:40356970
Melatonin-mediated intestinal microbiota homeostasis improves skin barrier damage involvement of gut-skin axis dysfunction in aging mice., PMID:40349812
Epithelial cells and fibroblasts are both activated via TGF-β1 and GSK-3β pathways differentially in the comorbidity of pulmonary fibrosis with lung adenocarcinoma., PMID:40349653
Monotropein synergizes with methotrexate to attenuate synovial inflammation in adjuvant-induced arthritis mice and fibroblast-like synoviocyte via GSK-3β., PMID:40349405
Lithium and neuroprotection: a review of molecular targets and biological effects at subtherapeutic concentrations in preclinical models of Alzheimer's disease., PMID:40348943
Study on the effect and mechanism of PM2.5 on the expression of Alzheimer's disease-like pathological proteins in SH-SY5Y cells., PMID:40348349
SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model., PMID:40346444
Impact of MiRNAs on Wnt-related gene activity in breast cancer., PMID:40346182
For research use only. Not for human or drug use.
