Catalog No.
YHE48701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe406-Phe513
Predicted molecular weight
11.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P46721
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OATP, OATP1, SLC21A3, OATP-A, Solute carrier family 21 member 3, Solute carrier organic anion transporter family member 1A2, OATP-1, Sodium-independent organic anion transporter, OATP1A2, Organic anion-transporting polypeptide 1, SLCO1A2
A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC., PMID:40379966
Identification and analysis of extracellular matrix and epithelial-mesenchymal transition-related genes in idiopathic pulmonary fibrosis by bioinformatics analysis and experimental validation., PMID:40187620
The effect of organic solvents on the in vitro transport activity of three OATP isoforms., PMID:40158752
Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer., PMID:40078312
Development of an OATP1-humanized transchromosomic mouse model for prediction of hepatic drug uptake in humans., PMID:40023577
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes., PMID:39251599
The Induction of Drug Uptake Transporter Organic Anion Transporting Polypeptide 1A2 by Radiation Is Mediated by the Nonreceptor Tyrosine Kinase v-YES-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1., PMID:39214663
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy., PMID:39152475
Expression of hepatic genes involved in bile acid metabolism in dairy cows with fatty liver., PMID:38825110
The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1., PMID:38432624
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy., PMID:38234807
Construction and validation of a prognostic model for colon adenocarcinoma based on bile acid metabolism-related genes., PMID:37543674
Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer., PMID:37055842
Correlation analysis of lipid metabolism genes with the immune microenvironment in gastric cancer and the construction of a novel gene signature., PMID:36520384
Impact of organic anion transporting polypeptide, P-glycoprotein, and breast cancer resistance protein transporters on observed tamoxifen and endoxifen concentration and adverse effects., PMID:36373739
Genetics of progressive supranuclear palsy in a Chinese population., PMID:35842134
Systematic identification and characterization of cynomolgus macaque solute carrier transporters., PMID:35081498
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis., PMID:34823432
Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin., PMID:34597623
Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics., PMID:34585840
Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2., PMID:34577133
Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes., PMID:33860121
First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2., PMID:33676726
SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma., PMID:33387348
Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor-β Signaling in Human Endothelial Cells., PMID:33168642
Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta., PMID:32768979
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone., PMID:32597704
OATP1A2 and OATP2B1 Are Interacting with Dopamine-Receptor Agonists and Antagonists., PMID:32343897
Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment., PMID:32304147
Transporter-enzyme interplay and the hepatic drug clearance: what have we learned so far?, PMID:32228316
Effects of Trough Concentration and Solute Carrier Polymorphisms on Imatinib Efficacy in Chinese Patients with Chronic Myeloid Leukemia., PMID:32027818
pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2., PMID:31974044
Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane., PMID:31776969
A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2., PMID:31770475
Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells., PMID:31746415
Membrane Transporters in Human Parotid Gland-Targeted Proteomics Approach., PMID:31569384
P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib., PMID:31304590
Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats., PMID:31063713
Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What Have We Learnt From the Genetic Variants of Drug Transporters., PMID:30931851
TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels., PMID:30682540
The 5'-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2., PMID:30348897
Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci., PMID:29986742
Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., PMID:29873816
Identification of a NFκB Inhibition Site on the Proximal Promoter Region of Human Organic Anion Transporting Polypeptide 1A2 Coding Gene SLCO1A2., PMID:29549185
Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers., PMID:29480324
Population nutrikinetics of green tea extract., PMID:29466429
Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia., PMID:29306656
Accurate Estimation of Functional Liver Volume Using Gd-EOB-DTPA MRI Compared to MDCT/99mTc-SPECT Fusion Imaging., PMID:28982888
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria., PMID:28975866
Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach., PMID:28928160
For research use only. Not for human or drug use.
