Catalog No.
YHD98501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys409
Predicted molecular weight
48.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32121
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARB2, ARR2, Non-visual arrestin-3, Beta-arrestin-2, ARRB2, Arrestin beta-2
Pinocembrin protects against cisplatin-induced liver injury via modulation of oxidative stress, TAK-1 inflammation, and apoptosis., PMID:40472974
Systems Genetics Reveals the Gene Regulatory Mechanisms of Arrb2 in the Development of Autism Spectrum Disorders., PMID:40428426
Tail-less precursors in synthetic cannabinoid production: investigating a clandestine laboratory, seized samples, and CB1 activity., PMID:40407906
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain., PMID:40393456
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and IFT machinery., PMID:40384633
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop., PMID:40350096
Deficiency of β-arrestin2 ameliorates MASLD in mice by promoting the activation of TAK1/AMPK signaling., PMID:40341987
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling., PMID:40302245
Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models., PMID:40254631
Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy., PMID:40236866
β-Arrestin 2 as a Prognostic Indicator and Immunomodulatory Factor in Multiple Myeloma., PMID:40214450
Correction to "Beta-Arrestin 2 Mediates Cardiac Hypertrophy Induced by Thyroid Hormones via AT1R"., PMID:40213894
Structure-Signal Relationships of the δ-Opioid-Receptor (DOR)-Selective Agonist KNT-127-Part II: Quinoline Ring Modifications for Enhanced G-Protein Signaling and Reduced β-Arrestin Recruitment., PMID:40204491
Physical TRPV1-PKR2 interaction modulates PKR2 localization, activation and β-arrestin-2 recruitment., PMID:40139621
LuQi formula ameliorates pressure overload-induced heart failure by regulating macrophages and regulatory T cells., PMID:40118747
In vivo neuroprotection in ischemic stroke by activated protein C requires β-arrestin 2., PMID:40093572
From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target., PMID:40093274
Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management., PMID:40006036
Enhanced Production and Functional Characterization of Recombinant Equine Chorionic Gonadotropin (rec-eCG) in CHO-DG44 Cells., PMID:40001592
In Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor-Mediated Signaling., PMID:40001198
GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability., PMID:39965073
β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility., PMID:39945280
N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation., PMID:39928858
Deletion of β-arrestin 2 in mice affects kappa opioid receptor-mediated behaviors depending on sex, ovariectomy status, and behavioral endpoints., PMID:39923977
Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2., PMID:39921112
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro., PMID:39881219
Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001., PMID:39868265
Novel tertiary diarylethylamines as functionally selective agonists of the kappa opioid receptor., PMID:39864528
Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations., PMID:39857630
Intracellular Pocket Conformations Determine Signaling Efficacy through the μ Opioid Receptor., PMID:39824514
Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation., PMID:39788289
Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery., PMID:39755133
Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial., PMID:39755132
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis., PMID:39741338
Thermodynamic role of receptor phosphorylation barcode in cannabinoid receptor desensitization., PMID:39693934
Intracellular pocket conformations determine signaling efficacy through the μ opioid receptor., PMID:39677660
β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy., PMID:39676815
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq., PMID:39675769
Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement., PMID:39623381
GPR88 impairs the signaling of kappa opioid receptors in a heterologous system and in primary striatal neurons., PMID:39613254
Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine., PMID:39565354
Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats., PMID:39557185
Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients., PMID:39545854
Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice., PMID:39521025
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor., PMID:39513765
Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonist., PMID:39495140
Mast cell MrgprB2 in neuroimmune interaction in IgE-mediated airway inflammation and its modulation by β-arrestin2., PMID:39483467
Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5., PMID:39472027
Assessment of high-efficacy agonism in synthetic cannabinoid receptor agonists containing l-tert-leucinate., PMID:39464043
Effects of positive mGlu5 modulation on D2 signaling and nicotine-conditioned place preference: Mechanisms of epigenetic inheritance in a transgenerational model of drug abuse vulnerability in psychosis., PMID:39462877
For research use only. Not for human or drug use.
