Catalog No.
YHP05901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg278-Val470
Predicted molecular weight
23.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6ZMU5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
TRIM72, Mitsugumin-53, MG53, Tripartite motif-containing protein 72, Mg53
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation., PMID:40494851
Acid-sensing ion channel 1a promotes LPS-induced acute lung injury through the circRNA 18-658/miR-127-5p/TRIM72 axis., PMID:40279987
Doxorubicin-induced apoptosis is exacerbated by MG53 and associated with altered Akt signaling in H9c2 cells., PMID:40222106
Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer's Disease Models., PMID:40149954
Suppression of TRIM72-mediated endoplasmic reticulum stress facilitates FOXM1 promotion of diabetic ulcer healing., PMID:39721954
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis., PMID:39709463
Trim72 is a major host factor protecting against lethal Candida albicans infection., PMID:39585917
Friend or Foe: The Paradoxical Roles of MG53 in Diabetes., PMID:39535840
MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues., PMID:39355613
TRIM72 inhibits cell migration and epithelial-mesenchymal transition by attenuating FAK/akt signaling in colorectal cancer., PMID:39315132
Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues., PMID:39281689
Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane., PMID:39267782
MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer., PMID:39265509
Nanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca2+ signaling., PMID:38779337
MG53/TRIM72: multi-organ repair protein and beyond., PMID:38681139
TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein., PMID:38408103
MG53: A new protagonist in the precise treatment of cardiomyopathies., PMID:38367817
Proteomic Identification of Seasonally Expressed Proteins Contributing to Heart Function and the Avoidance of Skeletal Muscle Disuse Atrophy in a Hibernating Mammal., PMID:38117800
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane., PMID:37770719
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats., PMID:37169128
Structural basis for TRIM72 oligomerization during membrane damage repair., PMID:36944613
Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway., PMID:36814155
TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation., PMID:36713032
Relationships between the abundance of 29 proteins and several meat or carcass quality traits in two bovine muscles revealed by a combination of univariate and multivariate analyses., PMID:36535620
ARH Family of ADP-Ribose-Acceptor Hydrolases., PMID:36497109
Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential., PMID:36291129
MG53 inhibits cellular proliferation and tumor progression in colorectal carcinoma., PMID:36147477
Cryo-EM structure of human MG53 homodimer., PMID:36053137
Integrated transcriptomic and proteomic analysis reveals potential targets for heart regeneration., PMID:35997993
TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells., PMID:35733226
Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway., PMID:35724457
MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress., PMID:35679798
Reduced Sarcolemmal Membrane Repair Exacerbates Striated Muscle Pathology in a Mouse Model of Duchenne Muscular Dystrophy., PMID:35563723
MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis., PMID:35438597
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA., PMID:35324524
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy., PMID:35170869
PARP1 is activated by membrane damage and is involved in membrane repair through poly(ADP-ribosyl)ation., PMID:35124853
Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma., PMID:35004288
Ubiquitination and degradation of MGMT by TRIM72 increases the sensitivity of uveal melanoma cells to Dacarbazine treatment., PMID:34958003
MG53 E3 Ligase-Dead Mutant Protects Diabetic Hearts From Acute Ischemic/Reperfusion Injury and Ameliorates Diet-Induced Cardiometabolic Damage., PMID:34844991
Chorionic villus-derived mesenchymal stem cells induce E3 ligase TRIM72 expression and regulate cell behaviors through ubiquitination of p53 in trophoblasts., PMID:34788479
The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis., PMID:34757120
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer., PMID:34521423
Cardiac effects and clinical applications of MG53., PMID:34183055
Editorial: Calcium Homeostasis in Skeletal Muscle Function, Plasticity, and Disease., PMID:33841193
Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake., PMID:33765605
Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates., PMID:33744959
MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle., PMID:33566837
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53., PMID:33400924
Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration., PMID:33240103
For research use only. Not for human or drug use.
