Catalog No.
YHN12901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr33-Asp361
Predicted molecular weight
39.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NBU5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATAD1, hATAD1, ATPase family AAA domain-containing protein 1, Outer mitochondrial transmembrane helix translocase, Thorase
Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation., PMID:40510765
ATAD1 Regulates Neuronal Development and Synapse Formation Through Tuning Mitochondrial Function., PMID:39795902
Mitochondrial YME1L1 governs unoccupied protein translocase channels., PMID:39774271
Cryo-EM Structure of AAA + ATPase Thorase Reveals Novel Helical Filament Formation., PMID:39605435
Analysis of protein trafficking between mitochondria and the endoplasmic reticulum by fluorescence microscopy., PMID:39488373
The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria., PMID:39089957
ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins., PMID:39024102
circ-ATAD1 as Competing Endogenous RNA for miR-191-5p Forces Non-small Cell Lung Cancer Progression., PMID:38079004
Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles., PMID:37984988
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria., PMID:37789674
The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission., PMID:37590302
Neonatal Hypertonia and Progressive Respiratory Failure due to Novel Heterozygous Mutation in ATAD1., PMID:36933275
Proofreading of protein localization mediated by a mitochondrial AAA-ATPase Msp1., PMID:36413760
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction., PMID:36409067
The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle., PMID:36278411
Conserved structural elements specialize ATAD1 as a membrane protein extraction machine., PMID:35550246
CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer., PMID:35505304
Circ-ATAD1 is overexpressed in osteosarcoma (OS) and suppresses the maturation of miR-154-5p to increase cell invasion and migration., PMID:34857012
ER-SURF: Riding the Endoplasmic Reticulum Surface to Mitochondria., PMID:34502567
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder., PMID:34351705
CircRNA circ-ATAD1 Is Upregulated in Cervical Squamous Cell Carcinoma and Regulates Cell Proliferation and Apoptosis by Suppressing the Maturation of miR-218., PMID:34254279
Transmembrane dislocases: a second chance for protein targeting., PMID:34147299
Quality control pathways of tail-anchored proteins., PMID:33285177
AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF., PMID:33147468
Mammalian Homologue NME3 of DYNAMO1 Regulates Peroxisome Division., PMID:33126676
Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities., PMID:32886535
A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis., PMID:32169278
Sorting out how Msp1 maintains mitochondrial membrane proteostasis., PMID:31394253
Mitochondrial AAA-ATPase Msp1 detects mislocalized tail-anchored proteins through a dual-recognition mechanism., PMID:30858337
10q23.31 microduplication encompassing PTEN decreases mTOR signalling activity and is associated with autosomal dominant primary microcephaly., PMID:30301738
ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation., PMID:29659736
Reply: ATAD1 encephalopathy and stiff baby syndrome: a recognizable clinical presentation., PMID:29659731
The AAA + ATPase Thorase is neuroprotective against ischemic injury., PMID:29658368
A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy., PMID:29390050
Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel., PMID:29237760
Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins., PMID:28712723
Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning., PMID:28103482
Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity., PMID:27306141
Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway., PMID:26777132
Role of AAA(+)-proteins in peroxisome biogenesis and function., PMID:26453804
Ganglioside regulation of AMPA receptor trafficking., PMID:25253868
Msp1: patrolling mitochondria for lost proteins., PMID:24916308
Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins., PMID:24843043
The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior., PMID:21496646
For research use only. Not for human or drug use.
