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Recombinant Mouse SNCA/Alpha-synuclein Protein, N-His

Catalog #:   YME22001 Specific References (49) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O55042
Protein length: Met1-Ala140
Overview

Catalog No.

YME22001

Expression system

E. coli

Species

Mouse

Protein length

Met1-Ala140

Predicted molecular weight

15.9 KDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O55042

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA

Data Image
References

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology., PMID:40523906

Amyloid formation of alternatively spliced variants of α-synuclein., PMID:40522183

Alpha-synuclein modulates the positioning of endolysosomes in melanoma cells., PMID:40521809

Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson's patient-derived midbrain neurons., PMID:40479066

GATA Transcription Factors: A Cross-Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies., PMID:40474753

Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice., PMID:40471880

Generation of iPSC lines with tagged α-synuclein for visualization of endogenous protein in human cellular models of neurodegenerative disorders., PMID:40456614

circ_0005654 as a Sponge of the miR-588 Dual Pathway to Promote α-Synuclein Expression., PMID:40444442

Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains., PMID:40436283

The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson's Disease., PMID:40427510

Systematic identification of SNCA as a key gene in ischemic cardiomyopathy via integrated weighted gene co-expression network analysis and experimental validation., PMID:40414013

The molecular basis of music-induced neuroplasticity in humans: A systematic review., PMID:40412457

Association of αS-SAA kinetics with clinical scores in the clinical spectrum of Parkinson's disease., PMID:40405674

Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson's disease., PMID:40404673

Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein., PMID:40395520

Exploring α-Syn's Functions Through Ablation Models: Physiological and Pathological Implications., PMID:40389720

ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson's disease., PMID:40379611

MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease., PMID:40367191

Identification of Hub Genes and Key Pathways Associated with Sepsis Progression Using Weighted Gene Co-Expression Network Analysis and Machine Learning., PMID:40362669

Neurogrit Gold Attenuates 6-OHDA-Induced Dopaminergic Neurodegeneration in Parkinson's Model of Caenorhabditis elegans by Reducing α-Synuclein Accumulation and Pink/Pdr-1 Driven Mitochondrial Dysfunction., PMID:40342222

Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone., PMID:40341765

Combined assessment of blood glucocerebrosidase activity and α-synuclein levels in GBA1 mutation carriers: A novel potential biomarker., PMID:40339261

Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy., PMID:40336104

GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies., PMID:40332088

Peripheral Immune pattern in a genetic cohort of p.A53T alpha-synuclein carriers., PMID:40328209

Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study., PMID:40315262

Widespread distribution of α-synuclein oligomers in LRRK2-related Parkinson's disease., PMID:40314842

The Nuclear Transitory Zone: A Key Player in the Cerebellar Development., PMID:40314748

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation., PMID:40268916

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells., PMID:40260646

Randomization based evaluation of distinct topological and cancer expression characteristics of mutually acting gene pairs., PMID:40257012

A ROS-Responsive nanoparticle for nuclear gene delivery and autophagy restoration in Parkinson's disease therapy., PMID:40245457

The potential of erythrocyte α-synuclein to differentiate dementia with Lewy bodies from Parkinson's and Alzheimer's diseases., PMID:40235217

Linking Parkinson's disease and melanoma: the impact of copper-driven cuproptosis and related mechanisms., PMID:40221422

Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy., PMID:40215824

Skin α-synuclein assays in diagnosing Parkinson's disease: a systematic review and meta-analysis., PMID:40205187

A fragment of Calpain-1 cleaved α-Synuclein quantified in serum is upregulated in patients with Parkinson's disease., PMID:40204767

Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson's disease., PMID:40204143

Myeloid FtH Regulates Macrophage Response to Kidney Injury by Modulating Snca and Ferroptosis., PMID:40196511

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner., PMID:40182046

Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review., PMID:40178685

Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits., PMID:40164505

R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation., PMID:40143425

Next Generation Sequencing Analysis in Patients Affected by Parkinson's Disease and Correlation Between Genotype and Phenotype in Selected Clinical Cases., PMID:40141040

Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson's Disease., PMID:40140103

Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy., PMID:40135351

α7-Nicotinic Acetylcholine Receptor and Mutated α-Synuclein Interact in Motor Behaviour and Nigrostriatal Dopamine-Findings With Potential Relevance for a Protective Effect of Cigarette Smoking and Parkinson's Disease., PMID:40125558

Recent developments in gene therapy for Parkinson's disease., PMID:40121531

Polyoxometalates bind multiple targets involved in Alzheimer's disease., PMID:40119889

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Mouse SNCA/Alpha-synuclein Protein, N-His [YME22001]
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