Anti-M6P Antibody (M6P-1)

Catalog No.

RGP14201

Species reactivity

General

Host species

Rabbit

Isotype

scFv

Clonality

Monoclonal

Target

M6P, mannose 6-phosphate, N-glycosylation

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

M6P-1

Antibodies to recombinant human alpha-L-iduronidase prevent disease correction in cortical bone in MPS I mice., PMID:40123743

Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors., PMID:39990570

Characterization of Site-Specific N- and O-Glycopeptides from Recombinant Spike and ACE2 Glycoproteins Using LC-MS/MS Analysis., PMID:39769415

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan., PMID:39434219

Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain., PMID:39382616

An updated management approach of Pompe disease patients with high-sustained anti-rhGAA IgG antibody titers: experience with bortezomib-based immunomodulation., PMID:38524130

Engineered arylsulfatase A with increased activity, stability and brain delivery for therapy of metachromatic leukodystrophy., PMID:37644722

Coronavirus Immunotherapeutic Consortium Database., PMID:36763096

Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation., PMID:35316032

Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment., PMID:32493818

A structured model for immune exposures., PMID:32283555

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation., PMID:31719144

Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice., PMID:31528541

Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†., PMID:26503547

Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2., PMID:26219725

Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy., PMID:25806780

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions., PMID:25601403

Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors., PMID:24033810

Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor., PMID:23984879

LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival., PMID:22849543

Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells., PMID:22768187

A connective tissue growth factor signaling receptor in corneal fibroblasts., PMID:22511630

Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy., PMID:21563231

Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells., PMID:21195083

Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages., PMID:20489197

Mannose phosphorylation in health and disease., PMID:19945768

Molecular analysis of cell lines from patients with mucolipidosis II and mucolipidosis III., PMID:19938078

Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor., PMID:19795464

CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis., PMID:19769965

Characterization of the mannose 6-phosphate receptor (Mr 300 kDa) protein dependent pathway of lysosomal enzyme targeting in Biomphalaria glabrata mollusc cells., PMID:19445999

Mannose-6-phosphate/insulin-like growth factor-II receptor in human melanoma cells: effect of ligands and antibodies on the receptor expression., PMID:19414391

Molecular cloning, expression and functional characterization of the chicken cation dependent mannose 6-phosphate receptor protein., PMID:18662714

Is the mannose-6-phosphate/insulin-like growth factor 2 receptor coded by a breast cancer suppressor gene?, PMID:18497053

A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis)., PMID:17471357

Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy., PMID:17044753

cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts., PMID:16644480

Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway., PMID:16407557

Analysis of glycosylation in CDG-Ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis: implications for extracellular glucose and intracellular mannose 6-phosphate., PMID:15708848

Latent TGF-beta1 activation by platelets., PMID:14978736

Possible angiogenic roles of insulin-like growth factor II and its receptors in uterine vascular adaptation to pregnancy., PMID:14557459

Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1., PMID:12851686

The role of insulin-like growth factor II and its receptor in mouse preimplantation development., PMID:12729502

Mannose-6-phosphate/insulin-like growth factor-II receptor expression levels during the progression from normal human mammary tissue to invasive breast carcinomas., PMID:12628843

Mifepristone-induced secretion of transforming growth factor beta1-induced apoptosis in prostate cancer cells., PMID:12429976

Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein., PMID:12083803

Processing of the insulin-like growth factor-II-mannose 6-phosphate receptor in isolated liver subcellular fractions., PMID:11527216

Identification of a type II insulin-like growth factor receptor in fish embryos., PMID:11181523

Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase., PMID:11014362

Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation., PMID:10900005

Synthesized TGF-beta s in RPE regulates cellular proliferation., PMID:10761392

Document Download

Anti-M6P Antibody (M6P-1).pdf