Catalog No.
YHG14002
Expression system
E. coli
Species
Human
Protein length
Gln563-Asp1051
Predicted molecular weight
59.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07890
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SOS-2, SOS2, Son of sevenless homolog 2
Helium governs nitric oxide signaling to improve alfalfa salinity tolerance by reestablishing redox and ion homeostasis., PMID:40412226
AtSERK1 and BAK1/AtSERK3 positively regulate seed germination in response to saline condition in Arabidopsis., PMID:40154002
The phytochrome B signaling regulates salt-mediated seedling growth in the dark., PMID:40103321
Ras-MAPK pathway in patients with lupus nephritis., PMID:40102014
SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD., PMID:40073053
Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts., PMID:40033301
Genome-Wide Identification and Characterization of gh/prl/sl Family in Cynoglossus semilaevis., PMID:40004051
SALT OVERLY SENSITIVE2 and AMMONIUM TRANSPORTER1;1 contribute to plant salt tolerance by maintaining ammonium uptake., PMID:39963720
Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells., PMID:39884044
Diurnal Regulation of SOS Pathway and Sodium Excretion Underlying Salinity Tolerance of Vigna marina., PMID:39853734
Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)., PMID:39818983
SOS2 phosphorylates FREE1 to regulate multi-vesicular body trafficking and vacuolar dynamics under salt stress., PMID:39792473
Exogenous 24-Epibrassinolide alleviates salt stress in Okra (Abelmoschus esculentus L.) by increasing the expression of SOS pathway genes (SOS1-3) and NHX1,4., PMID:39744325
Whole-genome resequencing reveals collagen-related genes in Kele pigs., PMID:39739914
Potential molecular mechanisms of tobacco smoke exposure in Alzheimer's disease., PMID:39694170
Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma., PMID:39488215
SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma., PMID:39437166
Combined sulforaphane and β-sitosterol mitigate olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling pathways., PMID:39116489
Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers., PMID:39087485
Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress., PMID:38965105
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading., PMID:38904222
SOS2-AFP2 module regulates seed germination by inducing ABI5 degradation in response to salt stress in Arabidopsis., PMID:38838447
CsSHMT3 gene enhances the growth and development in cucumber seedlings under salt stress., PMID:38696020
Undiagnosed RASopathies in infertile men., PMID:38654924
Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 in Arabidopsis thaliana., PMID:38386704
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography., PMID:38156904
SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma., PMID:38106234
SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma., PMID:38073064
High frequency of hotspot mutation in PTPN11 gene among Moroccan patients with Noonan syndrome., PMID:37987971
Illuminating (HTLV-1)-induced adult T-cell leukemia/lymphoma transcriptomic signature: A systems virology approach., PMID:37832654
Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinoma., PMID:37730692
The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis., PMID:37721807
GsPKS24, a calcineurin B-like protein-interacting protein kinase gene from Glycine soja, positively regulates tolerance to pH stress and ABA signal transduction., PMID:37596462
Phosphorylation of RhoGDI1, a Rho GDP dissociation inhibitor, regulates root hair development in Arabidopsis under salt stress., PMID:37590409
Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes., PMID:37493242
On salt stress, PLETHORA signaling maintains root meristems., PMID:37480843
A salt stress-activated GSO1-SOS2-SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion., PMID:37211994
SALT OVERLY SENSITIVE2 stabilizes phytochrome-interacting factors PIF4 and PIF5 to promote Arabidopsis shade avoidance., PMID:37119311
Phytochromes enhance SOS2-mediated PIF1 and PIF3 phosphorylation and degradation to promote Arabidopsis salt tolerance., PMID:37119239
SPAG9 Expression Predicts Good Prognosis in Patients with Clear-Cell Renal Cell Carcinoma: A Bioinformatics Analysis with Experimental Validation., PMID:37107702
Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer., PMID:37042566
Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients., PMID:37029817
Investigation into the genetics of fetal congenital lymphatic anomalies., PMID:36959127
Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress., PMID:36811145
Downregulation of miR-193a/b-3p during HPV-induced cervical carcinogenesis contributes to anchorage-independent growth through PI3K-AKT pathway regulators., PMID:36799263
Evaluation of differentially expressed genes during replication using gene expression landscape of monkeypox-infected MK2 cells: A bioinformatics and systems biology approach to understanding the genomic pattern of viral replication., PMID:36724696
RAP2.6 enhanced salt stress tolerance by reducing Na+ accumulation and stabilizing the electron transport in Arabidopsis thaliana., PMID:36634508
Phosphorylation of aldose-6-phosphate reductase from Prunus persica leaves., PMID:36508780
Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway., PMID:36396833
For research use only. Not for human or drug use.
