Catalog No.
RHN99501
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Mitogen-activated protein kinase kinase kinase kinase 1, MAP4K1, MAPK/ERK kinase kinase kinase 1, HPK1, MEK kinase kinase 1, MEKKK 1, Hematopoietic progenitor kinase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92918
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4C16
Hematopoietic progenitor kinase-1 inhibition improves the in vitro efficacy of bispecific antibodies in CLL., PMID:40101230
Research progress in bifunctional small molecules for cancer immunotherapy., PMID:39919914
Discovery of 1,2,4-benzotriazine derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors., PMID:39826501
Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients., PMID:39174331
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy., PMID:39084610
Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity., PMID:38685185
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress., PMID:38650383
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody., PMID:38350360
Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models., PMID:37944847
Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1., PMID:37339563
Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients., PMID:36213329
The development of small-molecule inhibitors targeting HPK1., PMID:36209628
Reduced expression of hematopoietic progenitor kinase 1 in T follicular helper cells causes autoimmunity of systemic lupus erythematosus., PMID:34968152
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function., PMID:33270695
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies., PMID:32860752
Multi-omic analysis reveals HIP-55-dependent regulation of cytokines release., PMID:32134471
Bioinformatics analyses on the immune status of renal transplant patients, a systemic research of renal transplantation., PMID:32046717
MAP4K Family Kinases in Immunity and Inflammation., PMID:26791862
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway., PMID:26437443
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade., PMID:26364751
Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways., PMID:24958882
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein., PMID:22902619
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK)., PMID:22334673
Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus., PMID:22014533
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses., PMID:17115060
Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival., PMID:14563325
Phage display based cloning of proteins interacting with the cytoplasmic tail of membrane immunoglobulins., PMID:12885153
Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways., PMID:12496419
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1., PMID:11514608
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1., PMID:10795738
For research use only. Not for human or drug use.
