Catalog No.
RHN97402
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:500-1:2000
Target
N2DL2, N2DL-2, UL16-binding protein 2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, NKG2D ligand 2, RAET1H, ULBP2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BZM5
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4B79
23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation., PMID:40116579
BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells., PMID:40029697
Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862
Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis., PMID:39026176
Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine-induced killer cell efficiency in multiple myeloma via the NKG2D pathway., PMID:38529413
Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease., PMID:38410511
Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells., PMID:37774496
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies., PMID:35587364
CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition., PMID:35003895
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen., PMID:34717050
The NKG2D ligand ULBP4 is not expressed by human monocytes., PMID:33556116
Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D., PMID:32698530
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting., PMID:32518350
An Immunosensor for the Detection of ULBP2 Biomarker., PMID:32503144
Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma., PMID:31737572
Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement., PMID:30541416
MG132 selectively upregulates MICB through the DNA damage response pathway in A549 cells., PMID:30483783
In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus., PMID:30008723
Natural Killer Cells Regulate Th17 Cells After Autologous Hematopoietic Stem Cell Transplantation for Relapsing Remitting Multiple Sclerosis., PMID:29867923
Combined inhibition of JAK1,2/Stat3‑PD‑L1 signaling pathway suppresses the immune escape of castration‑resistant prostate cancer to NK cells in hypoxia., PMID:29693186
Fusion Proteins of NKG2D/NKG2DL in Cancer Immunotherapy., PMID:29316666
CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells., PMID:28708284
Role of NKG2D in cytokine-induced killer cells against lung cancer., PMID:28529563
Immune response-associated gene analysis of 1,000 cancer patients using whole-exome sequencing and gene expression profiling-Project HOPE., PMID:27544999
Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30., PMID:26942070
NKG2D ligands mediate immunosurveillance of senescent cells., PMID:26878797
Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition., PMID:26595802
Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms., PMID:25473094
Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells., PMID:25212604
5-Fluorouracil and interleukin-2 immunochemotherapy enhances immunogenicity of non-small cell lung cancer A549 cells through upregulation of NKG2D ligands., PMID:24935593
The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma., PMID:24242212
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis., PMID:24136885
Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation., PMID:23937717
Valproic acid upregulates NKG2D ligand expression and enhances susceptibility of human renal carcinoma cells to NK cell-mediated cytotoxicity., PMID:23671445
Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma., PMID:23308050
Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity., PMID:23066150
The utility of a high-throughput scanning biosensor in the detection of the pancreatic cancer marker ULBP2., PMID:22959016
Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice., PMID:22806577
Genetic, immunological and clinical risk factors for biliary strictures following liver transplantation., PMID:22550960
Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors., PMID:22406996
NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study., PMID:22257486
Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity., PMID:22005785
Modulation of NKG2D-mediated cytotoxic functions of natural killer cells by viral protein R from HIV-1 primary isolates., PMID:21957298
Induction of in vitro and in vivo NK cell cytotoxicity using high-avidity immunoligands targeting prostate-specific membrane antigen in prostate carcinoma., PMID:21525185
Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells., PMID:21481337
Interleukin-10 promotes NK cell killing of autologous macrophages by stimulating expression of NKG2D ligands., PMID:20883317
Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis., PMID:20028385
Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases., PMID:19447870
Resistance to cytarabine induces the up-regulation of NKG2D ligands and enhances natural killer cell lysis of leukemic cells., PMID:19048119
Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH., PMID:19013003
For research use only. Not for human or drug use.
