Catalog No.
RHN93901
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
KIAA0571, GAB2, pp100, GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UQC2
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4B16
Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells., PMID:39987995
Fucosterol isolated from Sargassum horneri attenuates allergic responses in immunoglobulin E/bovine serum albumin-stimulated mast cells and passive cutaneous anaphylaxis in mice., PMID:38492337
Leaves and pseudostems extract of Curcuma longa attenuates immunoglobulin E/bovine serum albumin-stimulated bone marrow-derived cultured mast cell activation and passive cutaneous anaphylaxis in BALB/c mice., PMID:38042384
Potential Anti-allergic Effects of Bibenzyl Derivatives from Liverworts, Radula perrottetii., PMID:35081628
Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model., PMID:34836105
5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice., PMID:32531348
The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock., PMID:31847374
Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling., PMID:30861392
Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA., PMID:30800677
Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer., PMID:30755818
BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines., PMID:29326440
Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells., PMID:28891650
Ascites promotes cell migration through the repression of miR-125b in ovarian cancer., PMID:28881624
Antiallergic effect of fisetin on IgE-mediated mast cell activation in vitro and on passive cutaneous anaphylaxis (PCA)., PMID:28797929
Phosphoprotein profiles of candidate markers for early cellular responses to low-dose γ-radiation in normal human fibroblast cells., PMID:28122968
Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes., PMID:27861634
Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes., PMID:27025927
Blood Transcriptome Profiling in Myasthenia Gravis Patients to Assess Disease Activity: A Pilot RNA-seq Study., PMID:26924932
Adenine suppresses IgE-mediated mast cell activation., PMID:25700347
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function., PMID:24752297
Inhibitory effects of mulberry fruit extract in combination with naringinase on the allergic response in IgE-activated RBL-2H3 cells., PMID:24336971
Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer., PMID:24248418
Effect of endocannabinoids on IgE-mediated allergic response in RBL-2H3 cells., PMID:23731947
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells., PMID:23643722
The inhibitory activity of atractylenolide Ш, a sesquiterpenoid, on IgE-mediated mast cell activation and passive cutaneous anaphylaxis (PCA)., PMID:23149288
E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling., PMID:22859831
Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA., PMID:22564682
Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment., PMID:22517119
TSLP signaling network revealed by SILAC-based phosphoproteomics., PMID:22345495
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice., PMID:21746961
Ethyl acetate extract of Psidium guajava inhibits IgE-mediated allergic responses by blocking FcεRI signaling., PMID:20934477
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes., PMID:20532808
FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors., PMID:20101614
Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses., PMID:19508371
Houttuynia cordata water extract suppresses anaphylactic reaction and IgE-mediated allergic response by inhibiting multiple steps of FcepsilonRI signaling in mast cells., PMID:19394399
Gab2-mediated signaling promotes melanoma metastasis., PMID:19342374
Grb2 associated binder 2 couples B-cell receptor to cell survival., PMID:18950707
The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production., PMID:17579026
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration., PMID:17483340
The BCR signalosome: where cell fate is decided., PMID:16178270
The role of lipid rafts in LPS-induced signaling in a macrophage cell line., PMID:15904959
Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner., PMID:15852029
Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo., PMID:15684326
Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen., PMID:15542585
The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions., PMID:15240750
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects., PMID:15059917
The phenoxazine derivative Phx-1 suppresses IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells., PMID:15037819
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2., PMID:12819203
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells., PMID:12782712
Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent., PMID:12640125
For research use only. Not for human or drug use.
