Catalog No.
YHD77501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro39-His138
Predicted molecular weight
13.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28289
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E-Tmod, Erythrocyte tropomodulin, D9S57E, TMOD, Tropomodulin-1, TMOD1
The interaction of HT-2 toxin and Akt1 on gene expression regulation in Kashin-Beck disease pathogenesis., PMID:40449756
Tropomodulin-Tropomyosin Interplay Modulates Interaction Between Cardiac Myosin and Thin Filaments., PMID:40427620
Tropomodulin1 regulates the biomechanical changes in macrophages induced by matrix stiffness., PMID:40395777
Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis., PMID:39276234
Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2-mediated autophagy., PMID:39079577
H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation., PMID:38698061
Recessive TMOD1 mutation causes childhood cardiomyopathy., PMID:38168645
A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy., PMID:37126682
Suggestive evidence of the genetic association of TMOD1 and PTCSC2 polymorphisms with thyroid carcinoma in the Chinese Han population., PMID:36316666
Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture., PMID:35885988
Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide., PMID:35477741
Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton., PMID:35195928
CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle., PMID:33742108
Tropomodulin1 Expression Increases Upon Maturation in Dendritic Cells and Promotes Their Maturation and Immune Functions., PMID:33552047
Structural insights into the tropomodulin assembly at the pointed ends of actin filaments., PMID:33206408
MicroRNA-885 regulates the growth and epithelial mesenchymal transition of human liver cancer cells by suppressing tropomodulin 1 expression., PMID:32937160
Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments., PMID:32037094
Targeted regulation of miR-17-5p on TMOD1 promotes the development of cardia cancer., PMID:31364131
Quantitative proteomics reveals TMOD1-related proteins associated with water balance regulation., PMID:31339916
Bioinformatics analysis of microarray data to identify the candidate biomarkers of lung adenocarcinoma., PMID:31333911
Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding., PMID:30768849
Tropomyosin 3.5 protects the F-actin networks required for tissue biomechanical properties., PMID:30333143
Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation., PMID:30301754
The effect of shear on the cytoskeleton remodeling and physiological performance of myocardium cells through Tmod1., PMID:35548140
Therapeutic Effects of Coccomyxagloeobotrydiformis on the Metabolic Syndrome in Rats., PMID:30071531
Favorable prognostic role of tropomodulins in neuroblastoma., PMID:29930753
Characterizing interaction forces between actin and proteins of the tropomodulin family reveals the presence of the N-terminal actin-binding site in leiomodin., PMID:29223925
Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration., PMID:29143667
Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H., PMID:29105867
HSPB7 is indispensable for heart development by modulating actin filament assembly., PMID:29078393
The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics., PMID:28732641
Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome., PMID:28729432
Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c., PMID:28327132
Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease., PMID:28025995
Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells., PMID:27537257
Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin., PMID:27139341
Tropomodulin isoforms utilize specific binding functions to modulate dendrite development., PMID:27126680
Tropomyosin-binding properties modulate competition between tropomodulin isoforms., PMID:27091317
Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse., PMID:27073851
Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle., PMID:27065876
Localization of the binding interface between leiomodin-2 and α-tropomyosin., PMID:26873245
Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer., PMID:26718916
[Expression of microRNA in ALK-negative anaplastic large cell lymphoma and CD30-positive peripheral T cell lymphoma, not otherwise specified]., PMID:26705180
Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle., PMID:26586224
How Leiomodin and Tropomodulin use a common fold for different actin assembly functions., PMID:26370058
Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells., PMID:25740157
Cell type-restricted expression of erythrocyte tropomodulin Isoform41 in exon 1 knockout/LacZ knock-in heterozygous mice., PMID:25721257
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis., PMID:25431137
Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth., PMID:25398440
Transcriptome analysis of the human corneal endothelium., PMID:25377225
For research use only. Not for human or drug use.
