Catalog No.
RHN83102
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
PPP1R1B, Protein phosphatase 1 regulatory subunit 1B, DARPP32, Dopamine- and cAMP-regulated neuronal phosphoprotein, DARPP-32
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UD71
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4A44
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study., PMID:37769528
Transcriptome and chromatin landscape changes associated with trastuzumab resistance in HER2+ breast cancer cells., PMID:34224831
Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression., PMID:31740718
t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells., PMID:29180608
t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit., PMID:28867659
The Intracellular Signaling Molecule Darpp-32 Is a Marker for Principal Neurons in the Cerebellum and Cerebellum-Like Circuits of Zebrafish., PMID:27540357
Human t-DARPP is induced during striatal development., PMID:27475250
Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis., PMID:26483175
Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis., PMID:25779598
Experimental traumatic brain injury alters ethanol consumption and sensitivity., PMID:24934382
Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice., PMID:24086450
DARPP-32 to quantify intracerebral hemorrhage-induced neuronal death in basal ganglia., PMID:23543809
Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma., PMID:22745369
Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study., PMID:22179181
Colocalization of somatostatin receptors with DARPP-32 in cortex and striatum of rat brain., PMID:22116741
Levodopa treatment improves functional recovery after experimental stroke., PMID:22096034
Altered DARPP-32 expression in the superior temporal gyrus in schizophrenia., PMID:21453742
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors., PMID:20682746
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects., PMID:20494921
Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance., PMID:19593441
Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain., PMID:19465068
Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers., PMID:19301121
Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy., PMID:18808062
A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus., PMID:18479390
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo., PMID:17826804
Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion., PMID:17553006
For research use only. Not for human or drug use.
