Anti-RICTOR Antibody (R3Z03)

Catalog No.

RHK47101

Species reactivity

Human, Mouse, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

KIAA1999, Rapamycin-insensitive companion of mTOR, hAVO3, RICTOR, AVO3 homolog

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6R327

Applications

FCM, IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Z03

[Platelet-specific Rictor knockout inhibits platelet production and activation and reduces thrombosis in mice]., PMID:39276057

Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium., PMID:36890646

The traditional Chinese medicine Qiangjing tablet prevents blood-testis barrier injury induced by CdCl2 through the PI3K/Akt/Rictor signaling pathway., PMID:36370150

Whole blood transcriptome analysis in onchocerciasis., PMID:36082138

Longitudinal change of genetic variations in cetuximab-treated metastatic colorectal cancer., PMID:34315006

Mammalian target of rapamycin is activated in the kidneys of patients with scleroderma renal crisis., PMID:35382021

mTORC2 affects the maintenance of the muscle stem cell pool., PMID:31791403

Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer., PMID:31771139

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis., PMID:30783264

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts., PMID:30640966

The Effects of Different mTOR Inhibitors in EGFR Inhibitor Resistant Colon Carcinoma Cells., PMID:29882195

HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection., PMID:29475988

Rituximab effectively reverses Tyrosine kinase inhibitors (TKIs) resistance through inhibiting the accumulation of rictor on mitochondria-associated ER-membrane (MAM)., PMID:28946557

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients., PMID:28304242

mTOR activity and its prognostic significance in human colorectal carcinoma depending on C1 and C2 complex-related protein expression., PMID:27729429

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses., PMID:27690224

Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells., PMID:27099352

Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway., PMID:26890696

Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse., PMID:26780446

AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle., PMID:25887856

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma., PMID:25682871

Involvement of mTOR signaling pathways in regulating growth and dissemination of metastatic brain tumors via EMT., PMID:25667447

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis., PMID:25466898

Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus., PMID:24580843

Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip., PMID:24072685

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton., PMID:24006489

Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease., PMID:23979023

Requirement for Rictor in homeostasis and function of mature B lymphoid cells., PMID:23958952

Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex., PMID:23049074

Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells., PMID:22863784

The roles of REIC gene and its encoding product in gastric carcinoma., PMID:22421143

Placental DEPTOR as a stress sensor during pregnancy., PMID:21992080

Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells., PMID:21557327

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size., PMID:21266327

Differential expression of mTOR signalling components in drug resistance in ovarian cancer., PMID:20944133

Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes., PMID:20804212

Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid., PMID:20027631

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein., PMID:19299511

HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway., PMID:18250445

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes., PMID:16221682

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton., PMID:15268862

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Anti-RICTOR Antibody (R3Z03).pdf