Catalog No.
RHK40101
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
KIAA1303, Raptor, RAPTOR, RPTOR, Regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8N122
Applications
ELISA, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y87
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT., PMID:39661206
Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer., PMID:38302471
Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish., PMID:36724876
Effect of resistance training on satellite cells in old mice - a transcriptome study : implications for sarcopenia., PMID:35188421
Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor., PMID:33043385
mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion., PMID:32024827
Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis., PMID:29961810
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis., PMID:27913303
mTOR has distinct functions in generating versus sustaining humoral immunity., PMID:27760048
Down-regulation of phosphoglucose isomerase/autocrine motility factor enhances gensenoside Rh2 pharmacological action on leukemia KG1α cells., PMID:24606425
Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin., PMID:23283642
Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908., PMID:22356909
Placental DEPTOR as a stress sensor during pregnancy., PMID:21992080
Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)., PMID:21900751
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression., PMID:21576368
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding., PMID:21460630
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)., PMID:21071439
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes., PMID:20804212
Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes., PMID:20203102
Raptor is phosphorylated by cdc2 during mitosis., PMID:20169205
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation., PMID:19864431
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein., PMID:19299511
Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1., PMID:16798736
Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin., PMID:16428328
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton., PMID:15268862
For research use only. Not for human or drug use.
