Catalog No.
RHK36602
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial, SIR2-like protein 3, SIRT3, Regulatory protein SIR2 homolog 3, SIR2L3, hSIRT3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NTG7
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y76
SIRT3 Functions as an Eraser of Histone H3K9 Lactylation to Modulate Transcription for Inhibiting the Progression of Esophageal Cancer., PMID:40252727
The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential., PMID:40142268
Possible pathogenic mechanisms for doxorubicin-induced splenic atrophy in a human breast cancer xenograft mouse model., PMID:38943348
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis., PMID:37993768
Parkinson's disease neurons exhibit alterations in mitochondrial quality control proteins., PMID:37553379
NAD+ supplementation improves mAb productivity in CHO cells via a glucose metabolic shift., PMID:36717516
17β-estradiol suppresses H2O2-induced senescence in human umbilical vein endothelial cells by inducing autophagy through the PVT1/miR-31/SIRT3 axis., PMID:36584773
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3., PMID:35393905
Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3., PMID:34769322
Histone Acetyltransferase p300 Inhibitor Improves Coronary Flow Reserve in SIRT3 (Sirtuin 3) Knockout Mice., PMID:32865093
Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition., PMID:32463172
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells., PMID:32306906
17β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy., PMID:32172411
Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse., PMID:32068790
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase., PMID:31677030
Stimulation of Na+/K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPK/SIRT3/PPARγ Signaling Pathway., PMID:31636805
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions., PMID:30774023
Correction: Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia., PMID:29930768
Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice., PMID:29581157
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation., PMID:29277324
AGEs Decreased SIRT3 Expression and SIRT3 Activation Protected AGEs-Induced EPCs' Dysfunction and Strengthened Anti-oxidant Capacity., PMID:28032248
Post-translational modification by acetylation regulates the mitochondrial carnitine/acylcarnitine transport protein., PMID:27864727
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy., PMID:27423420
Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia., PMID:27270321
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells., PMID:26912655
Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage., PMID:26473372
SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients., PMID:26121130
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells., PMID:25152236
Mitochondrial acetylation and genetic models of Parkinson's disease., PMID:25149217
Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN., PMID:24669285
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development., PMID:24370889
Ethanol metabolism modifies hepatic protein acylation in mice., PMID:24073283
Cyclophilin D modulates mitochondrial acetylome., PMID:24062335
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation., PMID:23835326
Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis., PMID:23710283
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity., PMID:23159776
Non-histone lysine acetylated proteins in heart failure., PMID:22155497
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation., PMID:21639917
Mechanism-based affinity capture of sirtuins., PMID:21184005
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress., PMID:17437997
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases., PMID:16790548
For research use only. Not for human or drug use.
