Catalog No.
RHK20202
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Protein-lysine N-methyltransferase SETD2, HYPB, Histone-lysine N-methyltransferase SETD2, KMT3A, SET2, KIAA1732, Huntingtin yeast partner B, HIF-1, Huntingtin-interacting protein B, Huntingtin-interacting protein 1, HIP-1, Lysine N-methyltransferase 3A, SET domain-containing protein 2, p231HBP, SETD2, HIF1, hSET2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BYW2
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y55
Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study., PMID:40352587
Biomarker analyses from the phase III randomized CLEAR trial: lenvatinib plus pembrolizumab versus sunitinib in advanced renal cell carcinoma., PMID:39672382
An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies., PMID:37927802
Müllerian-Type Clear Cell Carcinoma of Donor Origin in a Male Patient with a Kidney Transplant: Ascertained by Molecular Testing., PMID:37887551
Profound tumor response to combined CTLA-4 and PD-1 inhibition in systemic fourth line therapy observed in a patient with hepatocellular carcinoma harboring SETD2 and LRP1B mutations., PMID:36379463
Complete Pathologic Response to Pembrolizumab and Axitinib in a Patient With Sarcomatoid RCC and Ocrelizumab-Treated Multiple Sclerosis., PMID:34973243
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity., PMID:34672954
Comparative Molecular Analysis of Primary Central Nervous System Lymphomas and Matched Vitreoretinal Lymphomas by Vitreous Liquid Biopsy., PMID:34576156
Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019., PMID:33936072
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways., PMID:32619406
Clinicopathologic characterization of malignant chondroblastoma: a neoplasm with locally aggressive behavior and metastatic potential that closely mimics chondroblastoma-like osteosarcoma., PMID:32601382
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma., PMID:32472114
Monitoring treatment efficacy and resistance in breast cancer patients via circulating tumor DNA genomic profiling., PMID:31867841
The histone methyltransferase Setd2 is indispensable for V(D)J recombination., PMID:31350389
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints., PMID:30967619
Novel insights into transcriptional dysregulation in colorectal cancer., PMID:29788743
H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation., PMID:29610279
Methylated α-tubulin antibodies recognize a new microtubule modification on mitotic microtubules., PMID:27594515
Improvement in survival end points of patients with metastatic renal cell carcinoma through sequential targeted therapy., PMID:27664394
Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2., PMID:26002201
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution., PMID:25790038
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development., PMID:24036311
Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis., PMID:20944102
For research use only. Not for human or drug use.
