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Research Grade Catumaxomab

Catalog #:   DHD17406 Specific References (100) DATASHEET
Host species: Mouse Hybrid Rat
Isotype: IgG2a-kappa/IgG2b-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD17406

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Mouse Hybrid Rat

Isotype

IgG2a-kappa/IgG2b-lambda

Clonality

Monoclonal

Target

Epithelial glycoprotein 314, hEGP314, Major gastrointestinal tumor-associated protein GA733-2, EGP314, TACSTD1, Adenocarcinoma-associated antigen, TROP1, EPCAM, Epithelial glycoprotein, KS 1/4 antigen, Tumor-associated calcium signal transducer 1, M4S1, CD326, Ep-CAM, EGP, Epithelial cell adhesion molecule, M1S2, KSA, Cell surface glycoprotein Trop-1, GA733-2, Epithelial cell surface antigen, MIC18, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Concentration

1.2 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16422 & P07766

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

PBS, pH 6.0, 0.2M Arg, 0.02% Tween 80

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Bispecific, Musmus G2a kappa, anti-EPCAM (Ho-3/TP-A-01) / Rat sp. G2b lambda, anti-CD3E (26/II/6-1.2), TPBs01, CAS: 509077-98-9

Clone ID

Catumaxomab

Data Image
References

Catumaxomab: in malignant ascites, PMID: 22676343

Catumaxomab: clinical development and future directions, PMID: 20190561

Catumaxomab--trifunctional anti-EpCAM antibody used to treat malignant ascites, PMID: 20624115

Bispecific antibodies for cancer therapy: A review, PMID: 29269044

Catumaxomab: a bispecific trifunctional antibody, PMID: 19927225

The contribution of catumaxomab in the treatment of malignant ascites in patients with ovarian cancer: a review of the literature, PMID: 23644922

Bispecific antibodies: design, therapy, perspectives, PMID: 29403265

Palliation of malignant ascites, PMID: 30903617

The evolving role of catumaxomab in gastric cancer, PMID: 18694358

Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy, PMID: 20347527

Catumaxomab with Activated T-cells Efficiently Lyses Chemoresistant EpCAM-positive Triple-negative Breast Cancer Cell Lines, PMID: 29970561

Catumaxomab with and without prednisolone premedication for the treatment of malignant ascites due to epithelial cancer: results of the randomised phase IIIb CASIMAS study, PMID: 24965536

The trifunctional antibody catumaxomab in treatment of malignant ascites and peritoneal carcinomatosis, PMID: 20919824

Re-challenge with catumaxomab in patients with malignant ascites: results from the SECIMAS study, PMID: 25367854

Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy, PMID: 32989604

Antibody Based EpCAM Targeted Therapy of Cancer, Review and Update, PMID: 29295696

Review of catumaxomab in the treatment of malignant ascites, PMID: 21188120

Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action, PMID: 20652245

Randomised phase II trial to investigate catumaxomab (anti-EpCAM × anti-CD3) for treatment of peritoneal carcinomatosis in patients with gastric cancer, PMID: 29988111

Immunotherapy of peritoneal carcinomatosis with catumaxomab, PMID: 21358211

The trifunctional antibody catumaxomab amplifies and shapes tumor-specific immunity when applied to gastric cancer patients in the adjuvant setting, PMID: 23955093

Management of drainage for malignant ascites in gynaecological cancer, PMID: 31825525

Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: a case report and review of the literature, PMID: 22744709

Immunological changes in the ascites of cancer patients after intraperitoneal administration of the bispecific antibody catumaxomab (anti-EpCAM×anti-CD3), PMID: 26049121

Novel monoclonal antibodies for cancer treatment: the trifunctional antibody catumaxomab (removab), PMID: 21716847

The role of relative lymphocyte count as a biomarker for the effect of catumaxomab on survival in malignant ascites patients: results from a phase II/III study, PMID: 24714773

Catumaxomab for the treatment of malignant ascites in patients with chemotherapy-refractory ovarian cancer: a phase II study, PMID: 25254563

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab, PMID: 26296970

A phase II study of catumaxomab administered intra- and postoperatively as part of a multimodal approach in primarily resectable gastric cancer, PMID: 25214034

Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites, PMID: 21702044

The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial, PMID: 20473913

Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients, PMID: 20565453

Alternative molecular formats and therapeutic applications for bispecific antibodies, PMID: 25637431

Intra- and postoperative catumaxomab in patients with epithelial ovarian cancer: safety and two-year efficacy results from a multicentre, single-arm, phase II study, PMID: 25225907

Catumaxomab: malignant ascites: unjustified marketing authorisation, PMID: 21180374

Molecule of the month: catumaxomab, PMID: 19609465

A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3, PMID: 25814216

Structural and functional characterization of the trifunctional antibody catumaxomab, PMID: 20418662

Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report, PMID: 24380380

Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors, PMID: 27058902

Transient lymphocyte decrease due to adhesion and migration following catumaxomab (anti-EpCAM x anti-CD3) treatment in vivo, PMID: 22551544

Regression of liver metastases after treatment with intraperitoneal catumaxomab for malignant ascites due to breast cancer, PMID: 23197249

Catumaxomab, a rat/murine hybrid trifunctional bispecific monoclonal antibody for the treatment of cancer, PMID: 18535935

Immunomonitoring results of a phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3), PMID: 22044753

Influence of catumaxomab on tumor cells in bone marrow and blood in ovarian cancer, PMID: 19443405

Intraperitoneal catumaxomab therapy in a cirrhotic patient with malignant ascites due to urethelial carcinoma: a case report, PMID: 23038231

First surgical experience of intraperitoneal treatment with the trifunctional antibody catumaxomab (anti-EpCam x anti-CD3) for epithelial ovarian cancer, PMID: 21778311

Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study, PMID: 17410361

Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x Anti-CD3): results of a phase 1/2 study, PMID: 19238019

Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: an open-label, multicenter, phase I/II trial, PMID: 21358214

Catumaxomab: First Approval., PMID:40304879

Contemporary Management of Malignant Ascites., PMID:40037156

Narrative review of malignant ascites: epidemiology, pathophysiology, assessment, and treatment., PMID:38644553

A pivotal decade for bispecific antibodies?, PMID:38465614

Using biomarkers to allocate patients in a response-adaptive clinical trial., PMID:38045870

Identification of potential therapeutic drugs targeting core genes for systemic lupus erythematosus (SLE) and coexisting COVID-19: Insights from bioinformatic analyses., PMID:38018597

Immunotherapy for Peritoneal Carcinomatosis: Challenges and Prospective Outcomes., PMID:37190310

Peritoneal carcinomatosis with intraperitoneal immunotherapy: current treatment options and perspectives., PMID:36107723

Construction of miRNA-regulated drug-pathway network to screen drug repurposing candidates for multiple sclerosis., PMID:35356949

Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study., PMID:34715784

Advances in the conventional clinical treatment for hepatoblastoma and therapeutic innovation., PMID:36474976

First time intravesically administered trifunctional antibody catumaxomab in patients with recurrent non-muscle invasive bladder cancer indicates high tolerability and local immunological activity., PMID:33837852

Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy., PMID:32989604

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines., PMID:32438548

Management of drainage for malignant ascites in gynaecological cancer., PMID:31825525

Engineering IgG-Like Bispecific Antibodies-An Overview., PMID:31544880

Single-Chain Variable Fragment-Based Bispecific Antibodies: Hitting Two Targets with One Sophisticated Arrow., PMID:31011631

Palliation of malignant ascites., PMID:30903617

Approval of First CAR-Ts: Have we Solved all Hurdles for ATMPs?, PMID:32634192

Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis., PMID:30364780

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis., PMID:30103457

Randomised phase II trial to investigate catumaxomab (anti-EpCAM × anti-CD3) for treatment of peritoneal carcinomatosis in patients with gastric cancer., PMID:29988111

Catumaxomab with Activated T-cells Efficiently Lyses Chemoresistant EpCAM-positive Triple-negative Breast Cancer Cell Lines., PMID:29970561

Bispecific antibodies: design, therapy, perspectives., PMID:29403265

Antibody Based EpCAM Targeted Therapy of Cancer, Review and Update., PMID:29295696

Bispecific antibodies for cancer therapy: A review., PMID:29269044

Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives., PMID:28531111

The development of bispecific antibodies and their applications in tumor immune escape., PMID:28469973

Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition., PMID:27966460

Intraperitoneal immunotherapy: historical perspectives and modern therapy., PMID:27834358

The current status of immunotherapy in peritoneal carcinomatosis., PMID:27530056

Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors., PMID:27058902

Bispecific antibodies and their applications., PMID:26692321

Outpatient Intraperitoneal Catumaxomab Therapy for Malignant Ascites Related to Advanced Gynecologic Neoplasms., PMID:26417039

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab., PMID:26296970

Single nucleotide polymorphisms of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential translational aspects., PMID:26115884

Immunological changes in the ascites of cancer patients after intraperitoneal administration of the bispecific antibody catumaxomab (anti-EpCAM×anti-CD3)., PMID:26049121

Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome., PMID:25991672

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro., PMID:25947366

A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3., PMID:25814216

Clinical pharmacology of bispecific antibody constructs., PMID:25707960

Alternative molecular formats and therapeutic applications for bispecific antibodies., PMID:25637431

A survey of treatment approaches of malignant ascites in Germany and Austria., PMID:25528551

Treatment of malignant ascites with a second cycle of catumaxomab in gastric signet cell carcinoma--a report of 2 cases., PMID:25427585

Re-challenge with catumaxomab in patients with malignant ascites: results from the SECIMAS study., PMID:25367854

Catumaxomab for the treatment of malignant ascites in patients with chemotherapy-refractory ovarian cancer: a phase II study., PMID:25254563

Intra- and postoperative catumaxomab in patients with epithelial ovarian cancer: safety and two-year efficacy results from a multicentre, single-arm, phase II study., PMID:25225907

A phase II study of catumaxomab administered intra- and postoperatively as part of a multimodal approach in primarily resectable gastric cancer., PMID:25214034

An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro., PMID:25075094

Catumaxomab with and without prednisolone premedication for the treatment of malignant ascites due to epithelial cancer: results of the randomised phase IIIb CASIMAS study., PMID:24965536

Datasheet

Document Download

Research Grade Catumaxomab.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

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Research Grade Catumaxomab [DHD17406]
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