Catalog No.
RHJ90505
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
PAM-1, JAM1, Platelet F11 receptor, JCAM, JAM-A, F11R, Junctional adhesion molecule A, Junctional adhesion molecule 1, CD321, Platelet adhesion molecule 1, JAM-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y624
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X77
Multilayered proteomics reveals that JAM-A promotes breast cancer progression via regulation of amino acid transporter LAT1., PMID:38943512
Targeting the tetraspanin CD81 reduces cancer invasion and metastasis., PMID:34099563
Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury., PMID:33737554
Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155., PMID:33185939
Generation of Genetically RGD σ1-Modified Oncolytic Reovirus That Enhances JAM-A-Independent Infection of Tumor Cells., PMID:32907973
Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders., PMID:29066542
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF., PMID:29034528
A novel immunotoxin reveals a new role for CD321 in endothelial cells., PMID:29028806
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients., PMID:28973837
Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches., PMID:28933642
Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma., PMID:28837251
Expression and prognostic value of JAM-A in gliomas., PMID:28677106
Identification of Human Junctional Adhesion Molecule 1 as a Functional Receptor for the Hom-1 Calicivirus on Human Cells., PMID:28196955
Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma., PMID:26847087
Urinary trypsin inhibitor attenuates LPS-induced endothelial barrier dysfunction by upregulation of vascular endothelial-cadherin expression., PMID:26681130
F11R mRNA expression and promoter polymorphisms in patients with rheumatoid arthritis., PMID:26230081
Junctional adhesion molecule-A promotes proliferation and inhibits apoptosis of gastric cancer., PMID:25916097
JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals., PMID:25420915
Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis and poor prognosis in human nasopharyngeal cancer., PMID:25416560
A phase I trial of single-agent reolysin in patients with relapsed multiple myeloma., PMID:25294913
Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution., PMID:24704627
Digestion of epithelial tight junction proteins by the commensal Clostridium perfringens., PMID:24072681
Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis., PMID:23922698
House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions., PMID:23592402
Integrity of the blood-testis barrier in healthy men after suppression of spermatogenesis with testosterone and levonorgestrel., PMID:23019303
A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori., PMID:23015492
A novel role for junctional adhesion molecule-A in tumor proliferation: modulation by an anti-JAM-A monoclonal antibody., PMID:22886345
Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection., PMID:22811534
Ligation of CD24 expressed by oral epithelial cells induces kinase dependent decrease in paracellular permeability mediated by tight junction proteins., PMID:21806966
Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America., PMID:21796504
Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids., PMID:21520057
Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro., PMID:21466663
Tight junctions in cancer metastasis., PMID:21196209
Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells., PMID:20932985
miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness., PMID:20818426
Silencing of the F11R gene reveals a role for F11R/JAM-A in the migration of inflamed vascular smooth muscle cells and in atherosclerosis., PMID:20627246
Junctional adhesion molecule-C is a soluble mediator of angiogenesis., PMID:20592283
Role of calcium signalling and phosphorylations in disruption of the epithelial junctions by Pseudomonas aeruginosa quorum sensing molecule., PMID:20434232
From touchdown to transcription: the reovirus cell entry pathway., PMID:20397070
Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells., PMID:20378847
Investigation of the binding preference of reovirus sigma1 for junctional adhesion molecule A by classical and steered molecular dynamics., PMID:20102214
Induction of JAM-A during differentiation of human THP-1 dendritic cells., PMID:19748485
Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS., PMID:19588976
The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind., PMID:19538321
Mechanisms of outside-in signaling at the tight junction by junctional adhesion molecule A., PMID:19538282
JAM-A expression positively correlates with poor prognosis in breast cancer patients., PMID:19533747
Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells., PMID:19433574
Junctional adhesion molecule A [corrected] expression in human endometrial carcinoma., PMID:19395995
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases., PMID:19258599
Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma., PMID:19250634
For research use only. Not for human or drug use.
