Catalog No.
RHJ73101
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UBN7
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3X27
Microtubule dynamics in cancer metastasis: Harnessing the underappreciated potential for therapeutic interventions., PMID:39349106
Targeting HDAC6 improves anti-CD47 immunotherapy., PMID:38414061
Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies., PMID:38086380
Expression of acetylated histones H3 and H4 and histone deacetylase enzymes HDAC1, HDAC2 and HDAC6 in simple mammary carcinomas of female dogs., PMID:38028583
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel., PMID:37681444
Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury., PMID:37641882
Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts., PMID:36865233
Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling., PMID:36810912
HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer., PMID:36270986
NOD2-mediated HDAC6/NF-κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure., PMID:36226351
HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling., PMID:36096670
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment., PMID:35752438
Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine., PMID:35682830
An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway., PMID:34915156
Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat., PMID:34888496
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences., PMID:34625713
A protocol to visualize cytosolic aggresome-like bodies using confocal microscopy., PMID:34337443
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition., PMID:33891869
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors., PMID:33783263
HDAC6-selective inhibitors enhance anticancer effects of paclitaxel in ovarian cancer cells., PMID:33574940
First-in-Class Selective HDAC6 Inhibitor (ACY-1215) Has a Highly Favorable Safety Profile in Patients with Relapsed and Refractory Lymphoma., PMID:33458921
A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation., PMID:33360352
HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model., PMID:33329575
An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation., PMID:33279862
HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21., PMID:32796032
Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma., PMID:32685017
The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy., PMID:32482755
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab., PMID:32350373
Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA., PMID:32128345
Wnt/β-Catenin Pathway-Regulated Fibromodulin Expression Is Crucial for Breast Cancer Metastasis and Inhibited by Aspirin., PMID:31824307
Novel targets for the treatment of relapsing multiple myeloma., PMID:31125526
HDAC6 Suppresses Let-7i-5p to Elicit TSP1/CD47-Mediated Anti-Tumorigenesis and Phagocytosis of Hepatocellular Carcinoma., PMID:30991448
HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action., PMID:30987296
Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic Localization, Decreases Its Phosphorylation, and Increases Detyrosination of Tubulin., PMID:30909412
The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death., PMID:30318510
Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription., PMID:30273544
Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress., PMID:30121389
The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer., PMID:29483217
MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma., PMID:29406621
HDAC inhibitors enhance the immunotherapy response of melanoma cells., PMID:29137331
Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma., PMID:29104288
Targeted Proteomic Analyses of Histone H4 Acetylation Changes Associated with Homologous-Recombination-Deficient High-Grade Serous Ovarian Carcinomas., PMID:28866885
HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies., PMID:28830887
Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS., PMID:28829415
Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6., PMID:28623308
Identification of zinc finger transcription factor EGR2 as a novel acetylated protein., PMID:28576496
Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics., PMID:28398261
Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor., PMID:28264055
Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice., PMID:28245046
Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium., PMID:27559293
For research use only. Not for human or drug use.
