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Anti-SPINK5 Antibody (R3W84)

Catalog #:   RHJ64203 Specific References (49) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: IHC
Accession: Q9NQ38
Overview

Catalog No.

RHJ64203

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200

Target

Lympho-epithelial Kazal-type-related inhibitor, SPINK5, LEKTI, Serine protease inhibitor Kazal-type 5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NQ38

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3W84

Data Image
  • Immunohistochemical
    IHC-P analysis of esophagus tissue by SPINK5 antibody (RHJ64203). IHC-P was performed using sections of the formalin-fixed paraffin-embedded esophagus tissue;Result: Squamous epithelial cells are positively stained at the cytoplasm.
References

Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324

Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome., PMID:39476295

Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601

Successful infliximab treatment in siblings with Netherton syndrome: Unveiling a novel SPINK5 gene variant and literature review., PMID:38419182

A novel immune-related model to predict prognosis and responsiveness to checkpoint and angiogenesis blockade therapy in advanced renal cancer., PMID:36998443

Prevalence of and risk factors for nutritional deficiency and food allergy in a cohort of 21 patients with Netherton syndrome., PMID:36705039

Biological treatments for pediatric Netherton syndrome., PMID:36619513

Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation., PMID:36569942

Ustekinumab therapy for Netherton syndrome., PMID:36419401

Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma., PMID:35487308

Outcomes of Systemic Treatment in Children and Adults With Netherton Syndrome: A Systematic Review., PMID:35464459

Successful treatment of Netherton syndrome with dupilumab: A case report and review of the literature., PMID:34862657

Netherton Syndrome: Case Report and Review of the Literature., PMID:34604321

Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis., PMID:34390440

A novel SPINK5 donor splice site variant in a child with Netherton syndrome., PMID:33534181

Netherton syndrome caused by compound heterozygous mutation, c.80A>G mutation in SPINK5 and large-sized genomic deletion mutation, and successful treatment of intravenous immunoglobulin., PMID:33452875

A novel SPINK5 mutation and successful subcutaneous immunoglobulin replacement therapy in a child with Netherton syndrome., PMID:32767583

Successful treatment with dupilumab of an adult with Netherton syndrome., PMID:32472705

Comel-Netherton syndrome: A local skin barrier defect in the absence of an underlying systemic immunodeficiency., PMID:31975472

Generation and Clinical Application of Gene-Modified Autologous Epidermal Sheets in Netherton Syndrome: Lessons Learned from a Phase 1 Trial., PMID:31288584

Hyper-IgE in the allergy clinic--when is it primary immunodeficiency?, PMID:30043993

[Pathogenesis of atopic dermatitis]., PMID:29404622

Desquamating Rash in a Patient with Undiagnosed Netherton Syndrome., PMID:29106927

The skin barrier function gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants., PMID:28213955

Intrafamily and Interfamilial Phenotype Variation and Immature Immunity in Patients With Netherton Syndrome and Finnish SPINK5 Founder Mutation., PMID:26865388

A case of netherton syndrome: successful treatment with omalizumab and pulse prednisolone and its effects on cytokines and immunoglobulin levels., PMID:26592187

Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms., PMID:25231147

IgE allergen component-based profiling and atopic manifestations in patients with Netherton syndrome., PMID:25159469

Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation., PMID:24390132

Factors that predict the clinical reactivity and tolerance in children with cow's milk allergy., PMID:23535094

Netherton syndrome in one Chinese adult with a novel mutation in the SPINK5 gene and immunohistochemical studies of LEKTI., PMID:22837558

[Expressions of receptor tyrosine kinases mRNA and protein in carcinoma of bladder]., PMID:21906447

Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis., PMID:21697885

Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans., PMID:21087323

A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2., PMID:20085599

Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)., PMID:19996348

Comèl-Netherton syndrome defined as primary immunodeficiency., PMID:19683336

Early skin biopsy is helpful for the diagnosis and management of neonatal and infantile erythrodermas., PMID:19615015

Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort., PMID:17989887

LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction., PMID:17596512

Netherton syndrome: report of identical twins presenting with severe atopic dermatitis., PMID:16670861

Netherton syndrome in two Japanese siblings with a novel mutation in the SPINK5 gene: immunohistochemical studies of LEKTI and other epidermal molecules., PMID:16225619

A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene., PMID:16120162

LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome., PMID:15606522

SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases., PMID:15304086

Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample., PMID:15005725

SPINK5: a gene for atopic dermatitis and asthma., PMID:15005722

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome., PMID:12915442

Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population., PMID:12752122

Datasheet

Document Download

Anti-SPINK5 Antibody (R3W84).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-SPINK5 Antibody (R3W84) [RHJ64203]
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