Catalog No.
RHJ52602
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200
Target
SLAM family member 4, SLAMF4, h2B4, Signaling lymphocytic activation molecule 4, Natural killer cell receptor 2B4, NKR2B4, NAIL, NK cell type I receptor protein 2B4, CD244, NK cell activation-inducing ligand, 2B4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BZW8
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3W29
LAG3 Is Expressed on Muscle-Infiltrating Cytotoxic T Cells, but Scarce on Circulating T Cells, in Patients With Inclusion Body Myositis., PMID:40485502
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study., PMID:40404633
NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity., PMID:39066329
Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma., PMID:38424542
Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options., PMID:35812458
The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and the induction of ferroptosis-related cell death., PMID:35706368
NK Cells Equipped With a Chimeric Antigen Receptor That Overcomes Inhibition by HLA Class I for Adoptive Transfer of CAR-NK Cells., PMID:35585985
Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection., PMID:35336991
Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications., PMID:34486371
Distinct Molecular Subtypes of Diffuse Large B Cell Lymphoma Patients Treated with Rituximab-CHOP Are Associated with Different Clinical Outcomes and Molecular Mechanisms., PMID:34250086
CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation., PMID:33936035
CD244+ polymorphonuclear myeloid‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model., PMID:33907826
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies., PMID:33730580
Human peripheral basophils extended phenotype shows a high expression of CD244 immuno-regulatory receptor., PMID:33493550
Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer., PMID:32630303
Identification of the association of CD28+ CD244+ Tc17/IFN-γ cells with chronic hepatitis C virus infection., PMID:32568409
Immune characterization of metastatic colorectal cancer patients post reovirus administration., PMID:32552875
Characterization of the Impact of Daclizumab Beta on Circulating Natural Killer Cells by Mass Cytometry., PMID:32391016
CD244 represents a new therapeutic target in head and neck squamous cell carcinoma., PMID:32217758
T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients., PMID:31869432
Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry., PMID:31160786
Increased exhausted CD8+ T cells with programmed death-1, T-cell immunoglobulin and mucin-domain-containing-3 phenotype in patients with multiple myeloma., PMID:29943497
Scrutinizing the Expression and Blockade of Inhibitory Molecules Expressed on T Cells from Acute Myeloid Leukemia Patients., PMID:29908544
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells., PMID:29535740
Intrahepatic and peripheral blood phenotypes of natural killer and T cells: differential surface expression of killer cell immunoglobulin-like receptors., PMID:29247515
Co-inhibitory profile and cytotoxicity of CD57+ PD-1- T cells in end-stage renal disease patients., PMID:29027667
Silver nanoparticles for the detection of cell surface antigens in mass cytometry., PMID:27351740
Human Diversity in a Cell Surface Receptor that Inhibits Autophagy., PMID:27345162
Modification of Expanded NK Cells with Chimeric Antigen Receptor mRNA for Adoptive Cellular Therapy., PMID:27177669
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction., PMID:26860368
2B4 Is Dispensable for T-Dependent B Cell Immune Responses, but Its Deficiency Leads to Enhanced T-Independent Responses Due to an Increase in Peritoneal Cavity B1b Cells., PMID:26323020
Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus., PMID:26314831
Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection., PMID:26150504
Immune checkpoint protein inhibition for cancer: preclinical justification for CTLA-4 and PD-1 blockade and new combinations., PMID:25965355
T cells Exhibit Reduced Signal Transducer and Activator of Transcription 5 Phosphorylation and Upregulated Coinhibitory Molecule Expression After Kidney Transplantation., PMID:25769075
Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components., PMID:25722295
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis., PMID:25189266
XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells., PMID:24496997
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses., PMID:24493803
PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads., PMID:24204962
Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors., PMID:24148617
Chicken SLAMF4 (CD244, 2B4), a receptor expressed on thrombocytes, monocytes, NK cells, and subsets of αβ-, γδ- T cells and B cells binds to SLAMF2., PMID:24055739
Involvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis., PMID:23638187
Enhancement of antigen-specific immunoglobulin G responses by anti-CD48., PMID:23208079
Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells., PMID:22786724
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus., PMID:22661557
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence., PMID:22438812
2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge., PMID:22230401
Association study of 3 rheumatoid arthritis risk loci in systemic sclerosis in European Caucasian population., PMID:21586211
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity., PMID:21622868
For research use only. Not for human or drug use.
