Catalog No.
RHJ50706
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
PINK1, BRPK, Serine/threonine-protein kinase PINK1, mitochondrial, PTEN-induced putative kinase protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BXM7
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3W19
Repurposing chlorpromazine for the treatment of triple-negative breast cancer growth and metastasis based on modulation of mitochondria-mediated apoptosis and autophagy/mitophagy., PMID:40217096
SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway., PMID:39826284
Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes., PMID:39477686
An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes., PMID:39273438
Zn0-Induced Cytotoxicity and Mitochondrial Stress in Microglia: Implications of the Protective Role of Immunoglobulin G In Vitro., PMID:39129512
Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles., PMID:38989951
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes., PMID:38987265
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue., PMID:38802071
Quadriceps muscle atrophy after non-invasive anterior cruciate ligament injury: evidence linking to autophagy and mitophagy., PMID:38496299
GRAF1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes., PMID:38474413
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue., PMID:38293125
Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation., PMID:38287905
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice., PMID:37768929
[Effect of acupotomy on mitophagy mediated by PINK1/Parkin pathway in cartilage of rabbits with knee osteoarthritis]., PMID:37730260
Autophagy and mitophagy-related extracellular mitochondrial dysfunction of cerebrospinal fluid cells in patients with hemorrhagic moyamoya disease., PMID:37612316
Parkinson's disease neurons exhibit alterations in mitochondrial quality control proteins., PMID:37553379
The necroptosis related gene LGALS3 can be used as a biomarker for the adverse progression from chronic HBV infection to HCC., PMID:37180150
Redefining Autoimmune Disorders' Pathoetiology: Implications for Mood and Psychotic Disorders' Association with Neurodegenerative and Classical Autoimmune Disorders., PMID:37174637
Resveratrol Protects against Zearalenone-Induced Mitochondrial Defects during Porcine Oocyte Maturation via PINK1/Parkin-Mediated Mitophagy., PMID:36136579
A novel nanoparticle system targeting damaged mitochondria for the treatment of Parkinson's disease., PMID:35913233
TNF-α Induces Mitophagy in Rheumatoid Arthritis Synovial Fibroblasts, and Mitophagy Inhibition Alleviates Synovitis in Collagen Antibody-Induced Arthritis., PMID:35628458
Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study., PMID:34421896
Preparation and characterization of a polyclonal antibody against PTEN-Long., PMID:34338347
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons., PMID:33758225
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC., PMID:33685343
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review., PMID:33615312
Inhibition of IL-6/JAK/STAT3 pathway rescues denervation-induced skeletal muscle atrophy., PMID:33490193
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms., PMID:33459343
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes., PMID:33404293
Assessing Chondrocyte Status by Immunofluorescence-Mediated Localization of Parkin Relative to Mitochondria., PMID:33315205
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples., PMID:33112198
Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2., PMID:32100342
The Michael J. Fox Foundation for Parkinson's Research Strategy to Advance Therapeutic Development of PINK1 and Parkin., PMID:31344817
Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy Through Negative Regulation of Pro-inflammatory Cytokine., PMID:31293430
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells., PMID:30707903
TIGAR inclusion pathology is specific for Lewy body diseases., PMID:30267647
Generation of induced pluripotent stem cell line (ZZUi007-A) from a 52-year-old patient with a novel CHCHD2 gene mutation in Parkinson's disease., PMID:30237140
PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism., PMID:30100261
Structure of PINK1 in complex with its substrate ubiquitin., PMID:29160309
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells., PMID:31966653
Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as Substrate., PMID:28573163
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis., PMID:28512249
Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells., PMID:28361483
Induction of PINK1/Parkin-Mediated Mitophagy., PMID:28361482
PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease., PMID:28213071
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects., PMID:27846363
RecQL4 regulates autophagy and apoptosis in U2OS cells., PMID:27813658
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis., PMID:27754761
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)., PMID:27456084
For research use only. Not for human or drug use.
