Catalog No.
RHJ43601
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
Radioprotective 105 kDa protein, Lymphocyte antigen 64, RP105, LY64, CD180 antigen, CD180
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99467
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V92
Disturbed Complement Receptor Expression Pattern of B Cells Is Enhanced by Toll-like Receptor CD180 Ligation in Diffuse Cutaneous Systemic Sclerosis., PMID:39273179
Toll-like Receptor Homologue CD180 Ligation of B Cells Upregulates Type I IFN Signature in Diffuse Cutaneous Systemic Sclerosis., PMID:39063175
Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells., PMID:37886369
Ligation of TLR Homologue CD180 of B Cells Activates the PI3K/Akt/mTOR Pathway in Systemic Sclerosis and Induces a Pathological Shift in the Expression of BAFF Receptors., PMID:35743222
High-Dimensional Analysis Reveals Distinct Endotypes in Patients With Idiopathic Inflammatory Myopathies., PMID:35371068
Single-cell RNA-Seq reveals transcriptional heterogeneity and immune subtypes associated with disease activity in human myasthenia gravis., PMID:34521820
Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders., PMID:34124274
A new score including CD43 and CD180: Increased diagnostic value for atypical chronic lymphocytic leukemia., PMID:34061467
A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza., PMID:33414788
B cell targeting by molecular adjuvants for enhanced immunogenicity., PMID:33252273
Toll-Like Receptor Mediated Activation of Natural Autoantibody Producing B Cell Subpopulations in an Autoimmune Disease Model., PMID:31817576
Ligation of CD180 contributes to endotoxic shock by regulating the accumulation and immunosuppressive activity of myeloid-derived suppressor cells through STAT3., PMID:30557700
CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus., PMID:30498494
Canine leishmaniasis: Genome-wide analysis and antibody response to Lutzomyia longipalpis saliva., PMID:29742167
Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide., PMID:29363546
Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization., PMID:29176765
PHAGOCYTOSIS AND EXPRESSION OF FCg-RECEPTORS AND CD180 ON MONOCYTES IN CHRONIC LYMPHOCYTIC LEUKEMIA., PMID:28972490
3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes., PMID:28384159
Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis., PMID:28236375
Proteomic profile of circulating immune complexes in chronic Chagas disease., PMID:27223052
Human CD180 Transmits Signals via the PIM-1L Kinase., PMID:26555723
Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations., PMID:26410072
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells., PMID:26277892
IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells., PMID:26276871
Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line., PMID:25879560
Aberrant expression of Fcγ-receptors and Toll like receptor CD180 on monocytes from patients with chronic lymphocytic leukaemia., PMID:25802446
Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy., PMID:25749095
Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor., PMID:25611435
B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis., PMID:25471597
Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia., PMID:24289109
An unexpected intriguing effect of Toll-like receptor regulator RP105 (CD180) on atherosclerosis formation with alterations on B-cell activation., PMID:24115036
Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory., PMID:24019553
Retinoic acid improves defective TLR9/RP105-induced immune responses in common variable immunodeficiency-derived B cells., PMID:24006462
TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells., PMID:23103284
The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2., PMID:22484241
Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse., PMID:22387632
[BCMA and autoantibody-producing RP105 B cells; possible new targets of B cell therapy in systemic lupus erythematosus]., PMID:22374441
RP105-negative B cells in systemic lupus erythematosus., PMID:21941580
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway., PMID:21918197
CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells., PMID:21443749
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica., PMID:21321193
Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling., PMID:20133206
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection., PMID:19258515
Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells., PMID:19124732
Increase of RP105-lacking activated B cells in the peripheral blood and salivary glands in patients with Sjögren's syndrome., PMID:18328140
Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis., PMID:17448566
Analysis of components of the CD14/TLR system on leukocytes of patients with atopic dermatitis., PMID:17284926
Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes., PMID:16225650
Vav proteins are required for B-lymphocyte responses to LPS., PMID:15811961
Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105., PMID:15742454
For research use only. Not for human or drug use.
