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Anti-HAS2 Antibody (R3V61)

Catalog #:   RHJ33401 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, IF, IHC, WB
Accession: Q92819
Overview

Catalog No.

RHJ33401

Species reactivity

Human, Mouse, Rat, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, IF: 1:100-1:500, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

HA synthase 2, Hyaluronan synthase 2, Hyaluronic acid synthase 2, HAS2, Hyaluronate synthase 2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q92819

Applications

ELISA, IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3V61

Data Image
  • Immunofluorescence
    Immunofluorescence analysis of HeLa cells using HAS2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using HAS2 mouse mAb with DAB staining.
  • Western blot
    Western blot analysis using HAS2 mouse mAb against NTERA-2 (1), HEK293 (2) cell lysate.
References

Metastatic tumor growth in steatotic liver is promoted by HAS2-mediated fibrotic tumor microenvironment., PMID:39946200

Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel disease., PMID:39782690

Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix., PMID:37156839

Hyaluronic acid restored protein permeability across injured human lung microvascular endothelial cells., PMID:36089980

Teprotumumab Divergently Alters Fibrocyte Gene Expression: Implications for Thyroid-associated Ophthalmopathy., PMID:35809263

Cell-Type-Specific Expression of Hyaluronan Synthases HAS2 and HAS3 Promotes Goblet Cell Hyperplasia in Allergic Airway Inflammation., PMID:35679095

Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies-the role of HAS2, SHB and HBEGF., PMID:35264144

Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice., PMID:35069543

The Potential Role of Osteopontin in the Pathogenesis of Graves' Ophthalmopathy., PMID:34546326

Dysregulation of Pulmonary Responses in Severe COVID-19., PMID:34064104

Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets., PMID:33718858

Effect of ligand-receptor interaction of osteopontin-CD44 on the expression of hyaluronic acid in human knee osteoarthritic chondrocytes in vitro., PMID:33051414

Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities., PMID:32610574

Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome., PMID:32028069

Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis., PMID:31570773

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity., PMID:31526718

Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration., PMID:31415646

Lactobacillus plantarum L-137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice., PMID:31273816

Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma., PMID:30857637

Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells., PMID:30365189

Hyaluronic acid synthase-2 gene transfer into the joints of Beagles by use of recombinant adeno-associated viral vectors., PMID:29688780

Potential treatment for vocal fold scar with pirfenidone., PMID:29171670

Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease., PMID:28787175

Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging., PMID:28482035

Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases., PMID:28234253

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer., PMID:28086235

Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion., PMID:27884164

[Endocrine orbitopathy - the topic still alive]., PMID:27734693

CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)., PMID:27595989

RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells., PMID:26900324

Distribution and characteristics of slow-cycling cells in rat vocal folds., PMID:26845229

The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome., PMID:26362804

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3., PMID:25795779

Cumulus cell-expressed type I interferons induce cumulus expansion in mice., PMID:25429090

Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novel B3GALT6 mutations., PMID:28649518

Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival., PMID:24337597

Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat., PMID:24099991

Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes., PMID:24057227

Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation., PMID:24023701

Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells., PMID:23979132

Disruption of canonical TGFβ-signaling in murine coronary progenitor cells by low level arsenic., PMID:23732083

Critical role of hyaluronidase-2 during preimplantation embryo development., PMID:23625939

Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2., PMID:23108409

Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes., PMID:23075113

EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement., PMID:22673225

Cell surface expression of hyaluronan on human ovarian cancer cells inversely correlates with their adhesion to peritoneal mesothelial cells., PMID:22392500

Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy., PMID:22162480

Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)., PMID:22016393

Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer., PMID:21913222

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44., PMID:21708929

Datasheet

Document Download

Anti-HAS2 Antibody (R3V61).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-HAS2 Antibody (R3V61) [RHJ33401]
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