Catalog No.
RHJ33401
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IF: 1:100-1:500, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
HA synthase 2, Hyaluronan synthase 2, Hyaluronic acid synthase 2, HAS2, Hyaluronate synthase 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92819
Applications
ELISA, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V61
Metastatic tumor growth in steatotic liver is promoted by HAS2-mediated fibrotic tumor microenvironment., PMID:39946200
Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel disease., PMID:39782690
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix., PMID:37156839
Hyaluronic acid restored protein permeability across injured human lung microvascular endothelial cells., PMID:36089980
Teprotumumab Divergently Alters Fibrocyte Gene Expression: Implications for Thyroid-associated Ophthalmopathy., PMID:35809263
Cell-Type-Specific Expression of Hyaluronan Synthases HAS2 and HAS3 Promotes Goblet Cell Hyperplasia in Allergic Airway Inflammation., PMID:35679095
Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies-the role of HAS2, SHB and HBEGF., PMID:35264144
Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice., PMID:35069543
The Potential Role of Osteopontin in the Pathogenesis of Graves' Ophthalmopathy., PMID:34546326
Dysregulation of Pulmonary Responses in Severe COVID-19., PMID:34064104
Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets., PMID:33718858
Effect of ligand-receptor interaction of osteopontin-CD44 on the expression of hyaluronic acid in human knee osteoarthritic chondrocytes in vitro., PMID:33051414
Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities., PMID:32610574
Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome., PMID:32028069
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis., PMID:31570773
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity., PMID:31526718
Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration., PMID:31415646
Lactobacillus plantarum L-137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice., PMID:31273816
Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma., PMID:30857637
Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells., PMID:30365189
Hyaluronic acid synthase-2 gene transfer into the joints of Beagles by use of recombinant adeno-associated viral vectors., PMID:29688780
Potential treatment for vocal fold scar with pirfenidone., PMID:29171670
Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease., PMID:28787175
Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging., PMID:28482035
Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases., PMID:28234253
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer., PMID:28086235
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion., PMID:27884164
[Endocrine orbitopathy - the topic still alive]., PMID:27734693
CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL)., PMID:27595989
RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells., PMID:26900324
Distribution and characteristics of slow-cycling cells in rat vocal folds., PMID:26845229
The reciprocal association between mammographic breast density, hyaluronan synthesis and patient outcome., PMID:26362804
Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3., PMID:25795779
Cumulus cell-expressed type I interferons induce cumulus expansion in mice., PMID:25429090
Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novel B3GALT6 mutations., PMID:28649518
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival., PMID:24337597
Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat., PMID:24099991
Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes., PMID:24057227
Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation., PMID:24023701
Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells., PMID:23979132
Disruption of canonical TGFβ-signaling in murine coronary progenitor cells by low level arsenic., PMID:23732083
Critical role of hyaluronidase-2 during preimplantation embryo development., PMID:23625939
Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2., PMID:23108409
Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes., PMID:23075113
EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement., PMID:22673225
Cell surface expression of hyaluronan on human ovarian cancer cells inversely correlates with their adhesion to peritoneal mesothelial cells., PMID:22392500
Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy., PMID:22162480
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)., PMID:22016393
Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer., PMID:21913222
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44., PMID:21708929
For research use only. Not for human or drug use.
