Catalog No.
RHJ33002
Species reactivity
Human, Mouse, Rat, Monkey
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
Histone deacetylase 2, HDAC2, HD2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92769
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V60
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis., PMID:39922804
Chidamide plus envafolimab as subsequent treatment in advanced non-small cell lung cancer patients resistant to anti-PD-1 therapy: A multicohort, open-label, phase II trial with biomarker analysis., PMID:38597130
RNA helicase DEAD-box-5 is involved in R-loop dynamics of preimplantation embryos., PMID:38419548
Expression of acetylated histones H3 and H4 and histone deacetylase enzymes HDAC1, HDAC2 and HDAC6 in simple mammary carcinomas of female dogs., PMID:38028583
Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer's Disease, healthspan and lifespan- Aging as a consequence of glycolysis., PMID:37398396
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499
Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway., PMID:35557040
Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats., PMID:34333051
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma., PMID:33637599
The anti-angiogenesis role of FBXW7 in diabetic retinopathy by facilitating the ubiquitination degradation of c-Myc to orchestrate the HDAC2., PMID:33369138
Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer., PMID:32934224
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment., PMID:32778095
iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice., PMID:32517688
(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo., PMID:31985048
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma., PMID:31304633
Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia., PMID:31066008
Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development., PMID:30765517
Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor., PMID:30587665
Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth., PMID:30071870
Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas., PMID:29025909
A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma., PMID:28892521
Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide., PMID:28578424
Identification of zinc finger transcription factor EGR2 as a novel acetylated protein., PMID:28576496
[INVOLVEMENT OF EPIGENETIC REGULATION IN CEREBRAL CELL DEATH FOLLOWING TRAUMATIC BRAIN INJURY IN A RAT MODEL]., PMID:28551908
Proteome-wide Mapping of Endogenous SUMOylation Sites in Mouse Testis., PMID:28289178
MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation., PMID:27884646
Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines., PMID:27250763
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells., PMID:27065318
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance., PMID:26980768
Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique., PMID:26863264
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro., PMID:26775659
A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells., PMID:26467746
JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus., PMID:26347123
Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy., PMID:26238735
Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer., PMID:25980579
HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis., PMID:25648995
A central role for TRPS1 in the control of cell cycle and cancer development., PMID:25277197
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome., PMID:25275504
Expression of histone deacetylases in diffuse large B-cell lymphoma and its clinical significance., PMID:25076845
Partial least squares based gene expression analysis in estrogen receptor positive and negative breast tumors., PMID:24488910
Histone deacetylase inhibitors as potential therapeutic approaches for chordoma: an immunohistochemical and functional analysis., PMID:23893747
Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque., PMID:23770939
Class I histone deacetylase activity is required for proliferation of renal epithelial cells., PMID:23698124
Dysregulation of histone deacetylase and histone acetyltransferase in development of Wegener's granulomatosis., PMID:23342555
SUMOylation of Blimp-1 is critical for plasma cell differentiation., PMID:22555612
Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts., PMID:22287608
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma., PMID:22156779
MRG15 activates the cdc2 promoter via histone acetylation in human cells., PMID:21324423
Tiotropium increases cytosolic muscarinic M3 receptors and acetylated H3 histone proteins in induced sputum cells of COPD patients., PMID:21147623
For research use only. Not for human or drug use.
