Catalog No.
RHJ31602
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IP: 1:100-1:200
Target
TSC, Hamartin, Tuberous sclerosis 1 protein, KIAA0243, TSC1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92574
Applications
IP
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3V57
CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance., PMID:40165206
Tissue-Based Biomarkers Important for Prognostication and Management of Genitourinary Tumors, Including Surrogate Markers of Genomic Alterations., PMID:39890303
Genomic Biomarkers Associated with Enfortumab Vedotin Outcomes for Patients with Advanced Urothelial Carcinoma: Analysis of UNITE Study Data., PMID:39709257
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT., PMID:39661206
The Clinicopathological Features of the Solitary Subependymal Giant Cell Astrocytoma: A Systematic Review., PMID:39216021
Complete Remission of a Diffuse Large B-Cell Lymphoma in a Young Patient, with Severe Tuberous Sclerosis, Treated with Metronomic Chemotherapy and Ibrutinib: A Case Report., PMID:37549660
A Phase I/II Investigation of Safety and Efficacy of Nivolumab and nab-Sirolimus in Patients With a Variety of Tumors With Genetic Mutations in the mTOR Pathway., PMID:37097693
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons., PMID:36627370
Tuberous sclerosis complex is associated with a novel human tauopathy., PMID:36469115
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer., PMID:35119931
Differential Modulation of Matrix Metalloproteinases-2 and -7 in LAM/TSC Cells., PMID:34944575
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells., PMID:34544857
Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1., PMID:34531523
Discovering Panel of Autoantibodies for Early Detection of Lung Cancer Based on Focused Protein Array., PMID:33968062
Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1., PMID:33936036
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes., PMID:33352197
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma., PMID:32472114
Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice., PMID:32375878
Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions., PMID:31437431
Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling., PMID:30988361
Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12., PMID:30792936
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc., PMID:30705387
Durable response to anti-PD-1 immunotherapy in epithelioid angiomyolipoma: a report on the successful treatment of a rare malignancy., PMID:30285856
Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis., PMID:30095976
Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration., PMID:29486577
Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice., PMID:29329496
CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc., PMID:28829945
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis., PMID:28512249
Role of mTOR signaling pathway in the pathogenesis of subependymal giant cell astrocytoma - A study of 28 cases., PMID:27625244
Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis., PMID:27289491
Lysosomal recruitment of TSC2 is a universal response to cellular stress., PMID:26868506
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21., PMID:26554817
TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation., PMID:26000908
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation., PMID:25816988
TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition., PMID:25727005
Oncotargets in different renal cancer subtypes., PMID:25619751
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators., PMID:25590233
Emerging therapeutic targets in bladder cancer., PMID:25498841
Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules., PMID:25411763
mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion., PMID:25332234
Tsc2 Haploinsufficiency Has Limited Effects on Fetal Brain Cytokine Levels during Gestational Immune Activation., PMID:25114803
Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1., PMID:24813888
TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival., PMID:24606538
Sirolimus decreases circulating lymphangioleiomyomatosis cells in patients with lymphangioleiomyomatosis., PMID:24051985
Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma., PMID:23871289
Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene., PMID:23867796
LAM cells biology and lymphangioleiomyomatosis., PMID:23690211
Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis., PMID:23665200
Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin., PMID:23426956
Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex., PMID:23049074
For research use only. Not for human or drug use.
