Catalog No.
YHD64201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly19-Ala259
Predicted molecular weight
29.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24855
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNL1, Deoxyribonuclease I, DNASE1, Dornase alfa, Deoxyribonuclease-1, DNase I, DRNI
Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil-Mediated Drug Delivery to In Vitro Thrombi., PMID:40341904
Different results despite high homology: Comparative expression of human and murine DNase1 in Pichia pastoris., PMID:40299953
[Electroacupuncture of "Jiaji" (EX-B2) inhibits neuroinflammatory response and glial scar formation by regulating the expression of neutrophil extracellular traps in mice with spinal cord injury]., PMID:40059047
A novel PRDM13 gene duplication causing congenital North Carolina macular dystrophy phenotype in a Mexican family., PMID:39959174
Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4., PMID:39777764
Role of DNase I in DNA degradation and cell-free DNA generation after acetaminophen-induced hepatic injury., PMID:39293964
A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models., PMID:38888971
Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition., PMID:38666340
Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction., PMID:38639358
The Dual Role of Neutrophil Extracellular Traps (NETs) in Sepsis and Ischemia-Reperfusion Injury: Comparative Analysis across Murine Models., PMID:38612596
Two novel non-coding single nucleotide variants in the DNase1 hypersensitivity site of PRDM13 causing North Carolina macular dystrophy in Korea., PMID:38601016
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2., PMID:38589685
Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)., PMID:38555846
R-tPA Resistance Is Specific for Platelet-Rich Stroke Thrombi and Can Be Overcome by Targeting Nonfibrin Components., PMID:38525646
A machine learning-based diagnostic model for myocardial infarction patients: Analysis of neutrophil extracellular traps-related genes and eQTL Mendelian randomization., PMID:38518057
NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain., PMID:38308301
Mesenchymal stem cells alleviate sepsis-induced acute lung injury by blocking neutrophil extracellular traps formation and inhibiting ferroptosis in rats., PMID:38304189
[Decreased DNase1L3 secretion and associated antibodies induce impaired degradation of NETs in patients with sporadic SLE]., PMID:38246176
TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization., PMID:38151453
Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions., PMID:38034352
Machine learning-based identification of CYBB and FCAR as potential neutrophil extracellular trap-related treatment targets in sepsis., PMID:37901228
The protective effect of DNase I in retinal vein occlusion., PMID:37838927
Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice., PMID:37804110
Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children., PMID:37474963
Targeting NETs using dual-active DNase1 variants., PMID:37287977
Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice., PMID:37131692
Genome Engineering of Human Urine-Derived Stem Cells to Express Lactoferrin and Deoxyribonuclease., PMID:37130035
Breaking bad., PMID:37129875
Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs., PMID:37075072
Multi-CpG linear regression models to accurately predict paclitaxel and docetaxel activity in cancer cell lines., PMID:36990534
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus., PMID:36969253
Identification of the regulatory mechanism of ACE2 in COVID-19-induced kidney damage with systems genetics approach., PMID:36951969
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms., PMID:36928522
Zwitterionic Polymer Coated and Aptamer Functionalized Flexible Micro-Electrode Arrays for In Vivo Cocaine Sensing and Electrophysiology., PMID:36838023
Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns., PMID:36825027
Curcumin Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Neutrophil Extracellular Traps Formation., PMID:36603844
Interleukin-37 alleviates myocardial injury induced by coxsackievirus B3 via inhibiting neutrophil extracellular traps formation., PMID:36308891
Hypercholesterolemia promotes autoantibody production and a lupus-like pathology via decreased DNase-mediated clearance of DNA., PMID:36098213
Significant Association of DNASE1 Variable Number Tandem Repeats and Single Nucleotide Polymorphisms With Gastric Cancer., PMID:35996518
Structural features of Dnase1L3 responsible for serum antigen clearance., PMID:35974043
Characteristics and genetic analysis of patients suspected with early-onset systemic lupus erythematosus., PMID:35964089
Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models., PMID:35793278
Origin and significance of the human DNase repertoire., PMID:35725583
Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection., PMID:35603144
Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus., PMID:35587043
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma., PMID:35474906
Effects of nucleases on cell-free extrachromosomal circular DNA., PMID:35451374
Identification of Alternative Splicing Events Associated with Paratuberculosis in Dairy Cattle Using Multi-Tissue RNA Sequencing Data., PMID:35328051
Mammalian nuclear speckles exhibit stable association with chromatin: a biochemical study., PMID:35220893
For research use only. Not for human or drug use.
