Catalog No.
RHH29601
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
CAMK, CaMK IV, CaM kinase-GR, CAMKIV, Calcium/calmodulin-dependent protein kinase type IV, CAMK-GR, CAMK4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16566
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3U38
Calcium calmodulin kinase IV deficiency in podocytes prevents the development of lupus nephritis., PMID:39793862
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression., PMID:38467629
CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses., PMID:38287012
Fasudil compensates podocyte injury via CaMK4/Rho GTPases signal and actin cytoskeleton-dependent activation of YAP in MRL/lpr mice., PMID:37094544
Inhibition of calcium/calmodulin-dependent protein kinase IV in arthritis: dual effect on Th17 cell activation and osteoclastogenesis., PMID:35781320
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro., PMID:35333675
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis., PMID:33784256
N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury., PMID:32531122
Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus., PMID:30462889
Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis., PMID:28698220
Hepatitis B virus X protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis., PMID:28216372
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function., PMID:26636664
In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen., PMID:26300304
IB4-binding sensory neurons in the adult rat express a novel 3' UTR-extended isoform of CaMK4 that is associated with its localization to axons., PMID:23817991
New therapeutics in systemic lupus erythematosus., PMID:23492737
Potential characteristics of stem cells from human exfoliated deciduous teeth compared with bone marrow-derived mesenchymal stem cells for mineralized tissue-forming cell biology., PMID:22099898
Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8., PMID:21303950
The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo., PMID:19776387
Temporal assessment of histone H3 phospho-acetylation and casein kinase 2 activation in dentate gyrus from ischemic rats., PMID:19765564
The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex., PMID:19538941
X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with protein kinase D., PMID:17494074
HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage., PMID:17038545
Identification of a biphasic signaling pathway involved in ischemic resistance of the hippocampal dentate gyrus., PMID:16996500
Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif., PMID:16036214
Regulation of the human atrial myosin light chain 1 promoter by Ca2+-calmodulin-dependent signaling pathways., PMID:15791000
Generation of a polyclonal antibody that simultaneously detects multiple Ser/Thr protein kinases., PMID:15236906
Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice., PMID:15229108
A new approach for the detection of multiple protein kinases using monoclonal antibodies directed to the highly conserved region of protein kinases., PMID:14596830
Involvement of calcium/calmodulin-dependent protein kinase II in the induction of mPer1., PMID:12692905
Activation of Ca2+/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons., PMID:12153482
Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway., PMID:11877414
Immunohistochemical localization of Ca(2+)/calmodulin-dependent protein kinase kinase beta in the rat central nervous system., PMID:11223463
A possible role for Ca(2+)/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus-secretion coupling., PMID:10838169
Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells., PMID:10656183
Distinct immunohistochemical localization of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain., PMID:10651863
High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini., PMID:10535305
Immunological evidence that the beta isoform of Ca2+/calmodulin-dependent protein kinase IV is a cerebellar granule cell-specific product of the CaM kinase IV gene., PMID:10383642
Differential effects of a calcineurin inhibitor on glutamate-induced phosphorylation of Ca2+/calmodulin-dependent protein kinases in cultured rat hippocampal neurons., PMID:10085155
Immunohistochemical localization of Ca2+/Calmodulin-dependent protein kinase IV in outer hair cells., PMID:9857208
Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation., PMID:9163554
Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy., PMID:8793097
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma., PMID:8615909
Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes., PMID:8530476
The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus., PMID:8194751
cDNA cloning and expression of human calmodulin-dependent protein kinase IV., PMID:8089075
A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1., PMID:8107230
Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex., PMID:2011593