Anti-MAPK14/p38 Antibody (R3U34)

Catalog No.

RHH28306

Species reactivity

Human, Mouse, Rat

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:50-1:100

Target

Stress-activated protein kinase 2a, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, SAPK2A, Cytokine suppressive anti-inflammatory drug-binding protein, CSBP, CSPB1, MAP kinase 14, MAP kinase MXI2, MAPK14, CSBP2, MAP kinase p38 alpha, MAPK 14, MXI2, CSAID-binding protein, MAX-interacting protein 2, CSBP1, SAPK2a

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q16539

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3U34

KDM5D histone demethylase mediates p38α inactivation via its enzymatic activity to inhibit cancer progression., PMID:39636854

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps., PMID:37752598

UPLC-Q-TOF-MS, network analysis, and molecular docking to investigate the effect and active ingredients of tea-seed oil against bacterial pathogens., PMID:37745048

Analysis of microRNA expression in rat kidneys after VEGF inhibitor treatment under different degrees of hypoxia., PMID:37642276

Intravesical BCG in bladder cancer induces innate immune responses against SARS-CoV-2., PMID:37520557

Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi., PMID:37356621

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps., PMID:37292963

Anti-CXCR2 antibody-coated nanoparticles with an erythrocyte-platelet hybrid membrane layer for atherosclerosis therapy., PMID:36898531

Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification., PMID:36217431

Network pharmacology-based analysis and experimental in vitro validation on the mechanism of Paeonia lactiflora Pall. in the treatment for type I allergy., PMID:35879791

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis., PMID:35806043

Panaxdiol saponins component promotes hematopoiesis by regulating GATA transcription factors of intracellular signaling pathway in mouse bone marrow., PMID:35282082

Identification and characterization of inhibitory nanobody against p38δ., PMID:35193074

Identification of covalent modifications regulating immune signaling complex composition and phenotype., PMID:34318608

Identification of Key Genes and Underlying Mechanisms in Acute Kawasaki Disease Based on Bioinformatics Analysis., PMID:34290221

TRPM2, PDLIM5, BCL3, CD14, GBA Genes as Feasible Markers for Premature Coronary Heart Disease Risk., PMID:34093636

Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy., PMID:33763111

Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages., PMID:33753566

Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation., PMID:33494411

Bone morphogenetic protein 7 promotes resistance to immunotherapy., PMID:32973129

Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1., PMID:32954947

CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer., PMID:32690037

Enhanced Immune Responses with Serum Proteomic Analysis of Hu Sheep to Foot-and-Mouth Disease Vaccine Emulsified in a Vegetable Oil Adjuvant., PMID:32326379

Functional effects of Tribbles homolog 2 in bovine ovarian granulosa cells†., PMID:32159216

Co-delivery of p38α MAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment., PMID:31972242

Hepatospecific ablation of p38α MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury., PMID:31601995

Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders., PMID:31427751

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells., PMID:30970259

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation., PMID:30771750

Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis., PMID:30541887

IP3-Mediated Calcium Signaling Is Involved in the Mechanism of Fractalkine-Induced Hyperalgesia Response., PMID:30517088

Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome., PMID:27474763

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells., PMID:26913608

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence., PMID:26802937

Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., PMID:26716417

The Relationship Between Colonic Macrophages and MicroRNA-128 in the Pathogenesis of Slow Transit Constipation., PMID:25749934

ω-3 PUFA rich camelina oil by-products improve the systemic metabolism and spleen cell functions in fattening pigs., PMID:25303320

Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis., PMID:25119169

The cellular thermal shift assay for evaluating drug target interactions in cells., PMID:25101824

Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells., PMID:24673557

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A., PMID:24215867

A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis., PMID:24121310

Interleukin-17A stimulates migration of periodontal ligament fibroblasts via p38 MAPK/NF-κB -dependent MMP-1 expression., PMID:23929359

[What's new in oncology?]., PMID:23522708

ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells., PMID:22521293

Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome., PMID:22310775

p38a MAPK is involved in BMP-2-induced odontoblastic differentiation of human dental pulp cells., PMID:21992459

Toll-like receptor 2 monoclonal antibody or/and Toll-like receptor 4 monoclonal antibody increase counts of Lactobacilli and Bifidobacteria in dextran sulfate sodium-induced colitis in mice., PMID:21722182

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity., PMID:21606507

p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells., PMID:20954847

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