Catalog No.
RHH09504
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000
Target
p90-RSK 1, Ribosomal S6 kinase 1, RSK1, p90RSK1, RPS6KA1, MAPKAP kinase 1a, MAPK-activated protein kinase 1a, RSK-1, MAPKAPK1A, MAP kinase-activated protein kinase 1a, MAPKAPK-1a, S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase alpha-1, p90S6K
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15418
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3T77
Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity., PMID:29615689
Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway., PMID:29449532
Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells., PMID:29048432
Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells., PMID:27300509
Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice., PMID:26135885
Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide., PMID:24058693
Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism., PMID:24036112
Self-antigen recognition by follicular lymphoma B-cell receptors., PMID:23024238
MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition., PMID:22249268
YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention., PMID:21576761
Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression., PMID:21340650
Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes., PMID:20203102
S6K1 deficiency protects against apoptosis in hepatocytes., PMID:19437488
ERK and p38 pathways regulate amino acid signalling., PMID:18809440
Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation., PMID:16751795
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3., PMID:15461589
Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors., PMID:15112576
Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland., PMID:12668683
Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases., PMID:11339820
Nuclear localization and regulation of erk- and rsk-encoded protein kinases., PMID:1545823
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity., PMID:2052581
For research use only. Not for human or drug use.
