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Anti-RPS6KA1 Antibody (R3T77)

Catalog #:   RHH09504 Specific References (21) DATASHEET
Host species: Mouse
Isotype: IgG2b
Applications: IHC
Accession: Q15418
Overview

Catalog No.

RHH09504

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

IHC: 1:200-1:1000

Target

p90-RSK 1, Ribosomal S6 kinase 1, RSK1, p90RSK1, RPS6KA1, MAPKAP kinase 1a, MAPK-activated protein kinase 1a, RSK-1, MAPKAPK1A, MAP kinase-activated protein kinase 1a, MAPKAPK-1a, S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase alpha-1, p90S6K

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15418

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3T77

Data Image
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human esophageal squamous cell carcinoma (A), colon adenocarcinoma (B), liver carcinoma (C), skin carcinoma (D), breast ductal tumor (E) and brain tumor (F), showing nuclear localization using RSK1 mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human small intestine tissues uing RSK1 mouse mAb.
References

Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity., PMID:29615689

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway., PMID:29449532

Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells., PMID:29048432

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells., PMID:27300509

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice., PMID:26135885

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide., PMID:24058693

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism., PMID:24036112

Self-antigen recognition by follicular lymphoma B-cell receptors., PMID:23024238

MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition., PMID:22249268

YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention., PMID:21576761

Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression., PMID:21340650

Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes., PMID:20203102

S6K1 deficiency protects against apoptosis in hepatocytes., PMID:19437488

ERK and p38 pathways regulate amino acid signalling., PMID:18809440

Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation., PMID:16751795

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3., PMID:15461589

Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors., PMID:15112576

Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland., PMID:12668683

Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases., PMID:11339820

Nuclear localization and regulation of erk- and rsk-encoded protein kinases., PMID:1545823

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity., PMID:2052581

Datasheet
$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-RPS6KA1 Antibody (R3T77) [RHH09504]
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