Catalog No.
RHG76802
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Src substrate cortactin, Oncogene EMS1, CTTN, Amplaxin, EMS1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14247
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3T17
Potential Biomarkers Associated with Prognosis and Trastuzumab Response in HER2+ Breast Cancer., PMID:37686651
A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells., PMID:34386076
Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis., PMID:33962172
[Not Available]., PMID:31082464
Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure., PMID:30665231
Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells., PMID:30568170
TKS5-positive invadopodia-like structures in human tumor surgical specimens., PMID:30439350
Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium., PMID:29075042
Diagnostic utility of cortactin antibodies in myasthenia gravis., PMID:29068555
Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells., PMID:25601713
Cortactin autoantibodies in myasthenia gravis., PMID:25193850
Identification of a novel myositis-associated antibody directed against cortactin., PMID:25182205
Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni., PMID:24188565
SRChing for the substrates of Src., PMID:24121272
Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia., PMID:23467367
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1., PMID:23144454
Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation., PMID:22898603
β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy., PMID:22378044
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells., PMID:22282019
Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways., PMID:21478254
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence., PMID:21079800
Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts., PMID:20650888
Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels., PMID:20542878
Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study., PMID:20213079
Localization of cortactin is associated with colorectal cancer development., PMID:19885549
Disruption of the cytoskeleton during Semaphorin 3A induced growth cone collapse correlates with differences in actin organization and associated binding proteins., PMID:19513995
Overexpression of cortactin in head and neck squamous cell carcinomas can be uncoupled from augmented EGF receptor expression., PMID:18607838
Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas., PMID:18575752
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin., PMID:17702746
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport., PMID:15821732
p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II., PMID:15618548
Alteration of podocytes in a murine model of crescentic glomerulonephritis., PMID:15258770
RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery., PMID:14742709
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton., PMID:12925758
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src., PMID:12851885
Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells., PMID:12782340
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton., PMID:12672817
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis., PMID:12612086
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin., PMID:12453877
The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells., PMID:12060669
Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions., PMID:11988077
CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524
Human cortactin as putative cancer antigen., PMID:11064458
Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape., PMID:11018064
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation., PMID:10442635
Characterization of the EMS1 gene and its product, human Cortactin., PMID:9823470
Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90., PMID:9813110
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells., PMID:9748248
Cortactin localization in actin-containing adult and fetal tissues., PMID:9742075
Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER., PMID:9722593
For research use only. Not for human or drug use.
