Catalog No.
RHG64302
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:250, IHC: 1:200-1:1000
Target
Acute myeloid leukemia 2 protein, PEBP2-alpha C, AML2, PEBP2A3, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, RUNX3, CBFA3, Polyomavirus enhancer-binding protein 2 alpha C subunit, CBF-alpha-3, Core-binding factor subunit alpha-3, PEA2-alpha C, Runt-related transcription factor 3, Oncogene AML-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13761
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S94
KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression., PMID:40460200
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient., PMID:39068234
USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation., PMID:38735043
Increased RUNX3 expression mediates tumor-promoting ability of human breast cancer-associated fibroblasts., PMID:37641472
Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells., PMID:37602826
Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease., PMID:37561593
RUNX3 regulates the susceptibility against EGFR-targeted non-small cell lung cancer therapy using 47Sc-conjugated cetuximab., PMID:37438719
Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy., PMID:37189103
Upregulated TSP1 and CD47 expression in the lung in nitrofen-induced congenital diaphragmatic hernia., PMID:36528876
CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation., PMID:36215676
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions., PMID:35604411
[RUNX3 regulates trastuzumab resistance of gastric cancer cells: a metabolomic analysis based on UPLC-Q Exactive Focus Orbitrap mass spectrometry]., PMID:35527485
Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients., PMID:35197967
Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism., PMID:34113353
The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution., PMID:34084162
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases., PMID:32128391
The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH)., PMID:30951700
Resident memory T cells, critical components in tumor immunology., PMID:30180905
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia., PMID:29547969
Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns., PMID:29535710
Identification of sequence variants influencing immunoglobulin levels., PMID:28628107
Localization of specialized intestinal metaplasia and the molecular alterations in Barrett esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol., PMID:27067780
Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions., PMID:26898755
Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling., PMID:26628061
DNA methylation and childhood asthma in the inner city., PMID:25769910
RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma., PMID:23851507
Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model., PMID:23383321
CpG island methylator phenotype and Helicobacter pylori infection associated with gastric cancer., PMID:23049225
CpG island methylator phenotype in plasma is associated with hepatocellular carcinoma prognosis., PMID:22180715
RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines., PMID:22179198
The pre-TCR signal induces transcriptional silencing of the TCRγ locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers., PMID:21750145
Screening and identification of host factors interacting with UL14 of herpes simplex virus 1., PMID:21512757
Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation., PMID:21425209
The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression., PMID:20930067
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation., PMID:20795789
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis., PMID:20714105
Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling., PMID:20142360
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation., PMID:20096094
Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation., PMID:20019337
IFN-gamma down-regulates TGF-beta1-induced IgA expression through Stat1 and p300 signaling., PMID:20016942
[Expression and localization of adenovirus-mediated transcriptional factor Runx3 in malignant glioblastoma cells]., PMID:19811728
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells., PMID:19800266
Analyses of TGF-beta1-inducible Ig germ-line gamma2b promoter activity: involvement of Smads and NF-kappaB., PMID:19266485
Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity., PMID:19233693
Runx3 expression in gastrointestinal tract epithelium: resolving the controversy., PMID:19169278
Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas., PMID:19015875
RUNX3 expression correlates with chief cell differentiation in human gastric cancers., PMID:19012242
RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression., PMID:18256927
Opposing effects of Arkadia and Smurf on TGFbeta1-induced IgA isotype expression., PMID:17978583
Runx-dependent regulation of G-protein gamma3 expression in T-cells., PMID:16904090
For research use only. Not for human or drug use.
