Catalog No.
RHG57702
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
FRP1, Serine/threonine-protein kinase ATR, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13535
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S63
Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis., PMID:40437523
Comparative analysis of pH shift-induced aggregation in IgG subclasses: Unveiling distinct pathways, mechanisms, and kinetics., PMID:40403800
A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC., PMID:40354992
Precision Medicine in High-Grade Serous Ovarian Cancer: Targeted Therapies and the Challenge of Chemoresistance., PMID:40141188
Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects against tumor rechallenge in mice., PMID:40139833
Magnetic Nanoparticles Stabilized by Phosphorylcholine-Containing Polymer for Label-Free C-Reactive Protein Detection., PMID:40124022
The influence of homologous recombination repair on temozolomide chemosensitivity in gliomas., PMID:40120126
Impact of DNA repair deficiency on sensitivity to antibody-drug conjugate (ADC) payloads in bladder cancer., PMID:40034244
Novel tissue biomarker candidates to predict both deep venous thrombosis and healing outcome after Achilles tendon rupture., PMID:40025102
Identification of molecular biomarkers in human serum for chronic kidney disease using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy., PMID:40024083
WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses., PMID:39984435
Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition., PMID:39874630
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein., PMID:39698847
IgE sensitization profiles to food, inhalant and insect venom in Norwegian blood donors and their impact on blood transfusions., PMID:39648460
Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer., PMID:39628575
Effects of in-ovo injection of Yu ping feng polysaccharides on growth performance, intestinal development, and immunity in broiler chickens., PMID:39616675
Therapeutic plasma exchange is associated with increased survival in heart transplant recipients experiencing severe primary graft dysfunction., PMID:39561862
FTIR monitoring of the 13-valent pneumococcal conjugate vaccine for lung cancer patients: Changes in amides vibrations correlated with biochemical assays., PMID:39427598
A multi-epitope protein vaccine encapsulated in alginate nanoparticles as a candidate vaccine against Shigella sonnei., PMID:39341926
Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite., PMID:39236403
Exploring novel circulating biomarkers for liver cancer through extracellular vesicle characterization with infrared spectroscopy and plasmonics., PMID:39122286
Spectrochemical and explainable artificial intelligence approaches for molecular level identification of the status of critically ill patients with COVID-19., PMID:39106646
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats., PMID:39049757
Homologous recombination proficient subtypes of high-grade serous ovarian cancer: treatment options for a poor prognosis group., PMID:38894867
A novel sustainable immunoassay for sensitive detection of atrazine based on the anti-idiotypic nanobody and recombinant full-length antibody., PMID:38882000
Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies., PMID:38845069
Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors., PMID:38786089
Evidence for persistent UV-induced DNA damage and altered DNA damage response in xeroderma pigmentosa patient corneas., PMID:38641197
Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma., PMID:38562878
Study of Monoclonal Antibody Aggregation at the Air-Liquid Interface under Flow by ATR-FTIR Spectroscopic Imaging., PMID:38445553
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment., PMID:38402224
Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification., PMID:38374092
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial., PMID:38351187
Preparation of Protein A Membranes Using Propargyl Methacrylate-Based Copolymers and Copper-Catalyzed Alkyne-Azide Click Chemistry., PMID:38257038
Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke., PMID:38178130
Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for ovarian cancer., PMID:38169532
PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition., PMID:38118413
Targeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2MUT ovarian cancer cells., PMID:38114660
Signal amplification of a quartz crystal microbalance immunosensor by gold nanoparticles-polyethyleneimine for hepatitis B biomarker detection., PMID:38071203
CD147: an integral and potential molecule to abrogate hallmarks of cancer., PMID:38023152
Atractylone in the Atractylodes macrocephala Rhizoma Essential Oil and Its Anti-Inflammatory Activity., PMID:37959758
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy., PMID:37932012
Comparative stability study and aggregate analysis of Bevacizumab marketed formulations using advanced analytical techniques., PMID:37810070
Studying the DNA damage response pathway in hematopoietic canine cancer cell lines, a necessary step for finding targets to generate new therapies to treat cancer in dogs., PMID:37655260
Small Cell Lung Cancer: Emerging Targets and Strategies for Precision Therapy., PMID:37627044
Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration., PMID:37441939
A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors., PMID:37377899
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial., PMID:37227187
Effectiveness of rituximab versus oral immunosuppressive therapies in neuromyelitis optica spectrum disorder in a racially diverse cohort of subjects: A single-center retrospective study., PMID:37086634
A label-free electrochemical immunosensor based on 11-mercaptoundecanoic acid grafted chitosan and poly(N-methylaniline) for the detection of carcinoembryonic antigen., PMID:37084572
For research use only. Not for human or drug use.
